Evidence map›Paper›PMID 21865361›Full record

ArticleThe Journal of clinical endocrinology and metabolism2011

Preferential fat deposition in subcutaneous versus visceral depots is associated with insulin sensitivity.

Tracey McLaughlin, Cindy Lamendola, Alice Liu, Fahim Abbasi

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03038620 (Impact of Liraglutide 3.0 on Body Fat Distribution, Visceral Adiposity, and Cardiometabolic Risk Markers In Overweight and Obese Adults at High Risk for Cardiovascular Disease), which is not on this map. Cited by 252 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
252citing papers in PubMed, 5 pooled it
16.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03038620 phase4completedstarted 2017, after this paper: background citation

Impact of Liraglutide 3.0 on Body Fat Distribution, Visceral Adiposity, and Cardiometabolic Risk Markers In Overweight and Obese Adults at High Risk for Cardiovascular Disease

Ran2017Enrolled235Registered outcomes37Posted comparisons0ConditionsCardiovascular Diseases, Fat Disorder, Obesity, VisceralArmsliraglutide, Placebo
PMID 19853906PMID 21844879PMID 23812094PMID 25538311PMID 26768490PMID 25808071PMID 15810802PMID 16182882PMID 17549449PMID 17707180PMID 18340209PMID 18356555other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

252 citing papers in PubMed, 5 syntheses or guidelines pooled it, 466 citations in OpenAlex.

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192 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Tracey McLaughlinDivision of Endocrinology, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, California 94305-5103, USA. tmclaugh@stanford.edu
Cindy Lamendola
Alice Liu
Fahim Abbasi
Stanford University · US

Funding

XOLAIR IN SUBJECTS WITH MODERATE TO SEVERE ATOPIC DERMATITIS WITH FOOD ALLERGYM01RR000070 · STANFORD UNIVERSITY · 1985 to 2005
$23.2M
Mentored Patient-Oriented Research Career Development AwK23RR016071 · STANFORD UNIVERSITY · 2000 to 2004
$627k
Integrating the Metabolic and Genetic Faces of ObesityR01DK071309 · STANFORD UNIVERSITY · 2005 to 2005
$345k
Integrating the Metabolic and Genetic Faces of ObesityR01DK071333 · STANFORD UNIVERSITY · 2005 to 2005
$235k
Intramural NIH HHSNCRR NIH HHS 5K23 RR16071NCRR NIH HHS K23 RR016071NCRR NIH HHS M01 RR000070NCRR NIH HHS RR 000070NIDDK NIH HHS 1 R01 DK071309-01NIDDK NIH HHS 5R01-DK071333NIDDK NIH HHS R01 DK071309NIDDK NIH HHS R01 DK071333
6 · The paper itself

Abstract

backgroundStudies on the relationship between regional fat and insulin resistance yield mixed results. Our objective was to determine whether regional fat distribution, independent of obesity, is associated with insulin resistance.

designSubjects included 115 healthy, overweight/moderately obese adults with body mass index (BMI) 25-36.9 kg/m(2) who met predetermined criteria for being insulin resistant (IR) or insulin sensitive (IS) based on the modified insulin suppression test. Computerized tomography was used to quantify visceral adipose tissue (VAT), sc adipose tissue (SAT), and thigh adipose tissue. Fat mass in each depot was compared according to IR/IS group, adjusting for BMI and sex.

resultsDespite nearly identical mean BMI in the IR vs. IS groups, VAT and %VAT were significantly higher in the IR group, whereas SAT, %SAT, and thigh sc fat were significantly lower. In logistic regression analysis, each sd increase in VAT increased the odds of being IR by 80%, whereas each increase in SAT decreased the odds by 48%; each increase in thigh fat decreased the odds by 59% and retained significance after adjusting for other depots. When grouped by VAT tertile, IS vs. IR individuals had significantly more SAT. There was no statistically significant interaction between sex and these relationships.

conclusionThese data demonstrate that after adjustment for BMI and VAT mass, sc abdominal and thigh fat are protective for insulin resistance, whereas VAT, after adjustment for SAT and BMI, has the opposite effect. Whether causal in nature or a marker of underlying pathology, these results clarify that regional distribution of fat-favoring sc depots is associated with lower risk for insulin resistance.

Indexed as

AdiposityAdultAgedBody Mass IndexFemaleHumansInsulin ResistanceIntra-Abdominal FatMaleMiddle AgedOverweightRadiographySex FactorsSubcutaneous Fat

Identifiers

PMID21865361
PMCPMC3205890
OpenAlexW2086823329

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.