ArticleAmerican journal of physiology. Heart and circulatory physiology2011
Splanchnic sympathetic nerves in the development of mild DOCA-salt hypertension.
Article in American journal of physiology. Heart and circulatory physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed, 40 citations in OpenAlex.
- The kidney distal tubule potassium switch, modern diet and hypertension.Nature reviews. Nephrology · 2026Review
- Central nervous system mechanisms of salt-sensitive hypertension.Physiological reviews · 2025Review
- Multi-Organ Denervation: The Past, Present and Future.Journal of clinical medicine · 2025Review
- Role of the median preoptic nucleus in the development of chronic deoxycorticosterone acetate (DOCA)-salt hypertension.Physiological reports · 2024Article
- DOCA-salt hypertension and the role of the OVLT-sympathetic-gut microbiome axis.Clinical and experimental pharmacology & physiology · 2021Article
- Renal Denervation and Celiac Ganglionectomy Decrease Mean Arterial Pressure Similarly in Genetically Hypertensive Schlager (BPH/2J) Mice.Hypertension (Dallas, Tex. : 1979) · 2021Article
- Activation of Orexin 1 Receptors in the Paraventricular Nucleus Contributes to the Development of Deoxycorticosterone Acetate-Salt Hypertension Through Regulation of Vasopressin.Frontiers in physiology · 2021Article
- Development of the Deoxycorticosterone Acetate (DOCA)-salt Hypertensive Rat Model.Bio-protocol · 2020Article
- Sympathetic Nervous System Contributions to Hypertension: Updates and Therapeutic Relevance.The Canadian journal of cardiology · 2020Review
- Renal Sympathetic Nerve-Derived Signaling in Acute and Chronic kidney Diseases.International journal of molecular sciences · 2020Review
- Effects of high-fat diet on sympathetic neurotransmission in mesenteric arteries from Dahl salt-sensitive rat.Autonomic neuroscience : basic & clinical · 2019Article
- Impaired Autonomic Nervous System-Microbiome Circuit in Hypertension.Circulation research · 2019Review
- Lesion of the OVLT markedly attenuates chronic DOCA-salt hypertension in rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2018Article
- Macrophage-dependent impairment of αAmerican journal of physiology. Heart and circulatory physiology · 2018Article
- DOCA-Salt Hypertension: an Update.Current hypertension reports · 2017Review
- Protective Role for Tissue Inhibitor of Metalloproteinase-4, a Novel Peroxisome Proliferator-Activated Receptor-γ Target Gene, in Smooth Muscle in Deoxycorticosterone Acetate-Salt Hypertension.Hypertension (Dallas, Tex. : 1979) · 2016Article
- Macrophage depletion lowers blood pressure and restores sympathetic nerve α2-adrenergic receptor function in mesenteric arteries of DOCA-salt hypertensive rats.American journal of physiology. Heart and circulatory physiology · 2015Article
- Alterations in perivascular innervation function in mesenteric arteries from offspring of diabetic rats.British journal of pharmacology · 2015Article
- Gαi2-protein-mediated signal transduction: central nervous system molecular mechanism countering the development of sodium-dependent hypertension.Hypertension (Dallas, Tex. : 1979) · 2015Article
- Brain Gαi 2 -subunit proteins and the prevention of salt sensitive hypertension.Frontiers in physiology · 2015Review
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2 authors at 1 institution in 1 country.
Funding
Abstract
We previously reported that mild deoxycorticosterone acetate (DOCA)-salt hypertension develops in the absence of generalized sympathoexcitation. However, sympathetic nervous system activity (SNA) is regionally heterogeneous, so we began to investigate the role of sympathetic nerves to specific regions. Our first study on that possibility revealed no contribution of renal nerves to hypertension development. The splanchnic sympathetic nerves are implicated in blood pressure (BP) regulation because splanchnic denervation effectively lowers BP in human hypertension. Here we tested the hypothesis that splanchnic SNA contributes to the development of mild DOCA-salt hypertension. Splanchnic denervation was achieved by celiac ganglionectomy (CGX) in one group of rats while another group underwent sham surgery (SHAM-GX). After DOCA treatment (50 mg/kg) in rats with both kidneys intact, CGX rats exhibited a significantly attenuated increase in BP compared with SHAM-GX rats (15.6 ± 2.2 vs. 25.6 ± 2.2 mmHg, day 28 after DOCA treatment). In other rats, whole body norepinephrine (NE) spillover, measured to determine if CGX attenuated hypertension development by reducing global SNA, was not found to be different between SHAM-GX and CGX rats. In a third group, nonhepatic splanchnic NE spillover was measured as an index of splanchnic SNA, but this was not different between SHAM (non-DOCA-treated) and DOCA rats during hypertension development. In a final group, CGX effectively abolished nonhepatic splanchnic NE spillover. These data suggest that an intact splanchnic innervation is necessary for mild DOCA-salt hypertension development but not increased splanchnic SNA or NE release. Increased splanchnic vascular reactivity to NE during DOCA-salt treatment is one possible explanation.
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