← Insulin × glycemic control

SynthesisThe Cochrane database of systematic reviews2011

Interventions for latent autoimmune diabetes (LADA) in adults.

Sinead Brophy et al.PubMed ↗Full text ↗Publisher ↗

  • Insulin alonelooks good hereLower long-term blood sugar.Randomised, large.
  • Insulinno clear effectHigher stimulated C-peptide.Nothing cleared the noise.
  • Chinese remediesno clear effectNo clear effect on fasting C-peptide levels.Nothing cleared the noise.

What the trial testedrandomised · 1,019 people · 2011

Randomised vs SU (with or without metformin)

Lowered long-term blood sugar

−1.30percentage points−2.40 to −0.10

insulin alone vs SU (with or without metformin)

As reported

difference −1.3 %, 95% CI −2.40 to −0.10 · the paper's word: glycosylated haemoglobin A1c (HbA1c) from baseline to end of study

Range includes no effect

No clear effect on fasting C-peptide levels

+0.07−0.05 to +0.19

Chinese remedies vs insulin alone

As reported

difference 0.07, 95% CI −0.05 to 0.19

Not counted

Raised stimulated C-peptide

+7.70ng/ml+2.90 to +12.5

insulin vs SU

As reported

difference 7.7 ng/ml, 95% CI 2.90–12.5

Who was studied, and how

1,019people with type 2 diabetes, in this paper

The trial randomly assignedassigned by chance

insulin alone
SU (with or without metformin)

Lowered long-term blood sugar−1.30

randomised

The trial randomly assignedassigned by chance

insulin
SU

Raised stimulated C-peptide+7.70

randomised

the abstract, start to end

… for insulin compared to oral therapy: -1.3% (95% confidence interval (CI) …

… than SU (one study, mean difference 7.7 ng/ml (95% CI 2.9 to 12.5)).

… levels compared to insulin alone (0.07 µg/L (95% CI -0.05 to 0.19).

← favours treatmentfavours comparator →
could be chance
Glycosylated haemoglobin A1c (HbA1c) from baseline to end of studyinsulin alone vs SU (with or without metformin)
−1.3−2.40 to −0.10
Stimulated C-peptideinsulin vs SU
7.72.90–12.5
Fasting C-peptide levelsChinese remedies vs insulin alone
0.07−0.05 to 0.19
InsulinGlycemic control
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Full record →Abstract, authors, funding and every citing paper · PMID 21901702