ArticleJournal of applied physiology (Bethesda, Md. : 1985)2011
Plasma norepinephrine is an independent predictor of vascular endothelial function with aging in healthy women.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 45 citations in OpenAlex.
- Comparison of Resveratrol Supplementation and Energy Restriction Effects on Sympathetic Nervous System Activity and Vascular Reactivity: A Randomized Clinical Trial.Molecules (Basel, Switzerland) · 2021Trial
- The impact of aircraft noise on vascular and cardiac function in relation to noise event number: a randomized trial.Cardiovascular research · 2021Trial
- Asymmetric and Symmetric Dimethylarginine and Sympathetic Nerve Traffic after Renal Denervation in Patients with Resistant Hypertension.Clinical journal of the American Society of Nephrology : CJASN · 2015Trial
- Effect of nighttime aircraft noise exposure on endothelial function and stress hormone release in healthy adults.European heart journal · 2013Trial
- Bone mechanical loading reduces heart rate and increases heart rate variability in mice.Bone reports · 2025Article
- Does endothelial ischemic reperfusion injury augment sympathetic neurovascular transduction?Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2024Article
- Occupational and Environmental Noise Exposure and Extra-Auditory Effects on Humans: A Systematic Literature Review.GeoHealth · 2023Review
- Role of BHAmerican journal of physiology. Heart and circulatory physiology · 2022Article
- Decline in endothelial function across the menopause transition in healthy women is related to decreased estradiol and increased oxidative stress.GeroScience · 2020 · on this mapArticle
- Syndecan-4 as a Marker of Endothelial Dysfunction in Patients with Resistant Hypertension.Journal of clinical medicine · 2020Article
- Inflammation as a mediator of arterial ageing.Experimental physiology · 2019Review
- Effect of Different Classes of Antihypertensive Drugs on Endothelial Function and Inflammation.International journal of molecular sciences · 2019Review
- Article
- Elevated Muscle Sympathetic Nerve Activity Contributes to Central Artery Stiffness in Young and Middle-Age/Older Adults.Hypertension (Dallas, Tex. : 1979) · 2019Article
- Article
- Proinflammatory Arterial Stiffness Syndrome: A Signature of Large Arterial Aging.Journal of vascular research · 2018Review
- Aging-Induced Biological Changes and Cardiovascular Diseases.BioMed research international · 2018Review
- Cellular and molecular biology of aging endothelial cells.Journal of molecular and cellular cardiology · 2015Review
- The mechanisms underlying fructose-induced hypertension: a review.Journal of hypertension · 2015Review
- The Relationship between Vascular Function and the Autonomic Nervous System.Annals of vascular diseases · 2014Review
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
We tested the hypothesis that reductions in vascular endothelial function (endothelium-dependent dilation, EDD) with age are related to increases in sympathetic activity. Among 314 healthy men and women, age was inversely related to brachial artery flow-mediated dilation (FMD) (r = -0.30, P < 0.001), a measure of EDD, and positively related to plasma norepinephrine concentrations (PNE), a marker of sympathetic activity (r = 0.49, P < 0.001). Brachial FMD was inversely related to PNE in all subjects (r = -0.25, P < 0.001) and in men (n = 187, r = -0.17, P = 0.02) and women (n = 127, r = -0.37, P < 0.001) separately. After controlling for PNE (multiple regression analysis), brachial FMD remained significantly related to age in all subjects (r = -0.20, P < 0.001) and in men (r = -0.23, P < 0.01), but not women (r = -0.16, P = 0.06). Consistent with this, brachial FMD remained significantly related to PNE when controlling for age (r = -0.24, P < 0.01) and menopause status (r = -0.24, P < 0.01) in women. Indeed, PNE was the strongest independent correlate of brachial FMD in women after controlling for conventional cardiovascular disease risk factors (r = -0.22, P = 0.01). This relation persisted in a subset of women (n = 113) after further accounting for the effects of plasma oxidized low-density lipoprotein (P < 0.05), a circulating marker of oxidative stress. Endothelium-independent dilation was not related to age in either men or women (P > 0.05). These results provide the first evidence that EDD is inversely related to sympathetic activity, as assessed by PNE, among healthy adults varying in age. In particular, our findings suggest that sympathetic nervous system activity may be a key factor involved in the modulation of vascular endothelial function with aging in women.
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