ArticleThe Journal of physiology2011
Twelve weeks of treadmill exercise does not alter age-dependent chronic kidney disease in the Fisher 344 male rat.
Article in The Journal of physiology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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18 citing papers in PubMed, 27 citations in OpenAlex.
- Review
- The preventive effects of exercise on renal dysfunction in D-galactose treated rats: the role of miR-296-5p and SGLT2.European journal of applied physiology · 2026Article
- Musculoskeletal Health Worsened from Carnitine Supplementation and Not Impacted by a Novel Individualized Treadmill Training Protocol.American journal of nephrology · 2024Article
- The effects of exercise on kidney injury: the role of SIRT1.Molecular biology reports · 2022Review
- Treadmill Exercise Training Ameliorates Functional and Structural Age-Associated Kidney Changes in Male Albino Rats.TheScientificWorldJournal · 2021Article
- Effects of treadmill running in a rat model of chronic kidney disease.Biochemistry and biophysics reports · 2018Article
- Oxidative stress response and Nrf2 signaling in aging.Free radical biology & medicine · 2015Review
- Long-term intermittent glutamine supplementation repairs intestinal damage (structure and functional mass) with advanced age: assessment with plasma citrulline in a rodent model.The journal of nutrition, health & aging · 2014Article
- Cardiac function is preserved following 4 weeks of voluntary wheel running in a rodent model of chronic kidney disease.Journal of applied physiology (Bethesda, Md. : 1985) · 2014Article
- Voluntary wheel running augments aortic l-arginine transport and endothelial function in rats with chronic kidney disease.American journal of physiology. Renal physiology · 2014Article
- Cardiac function and tolerance to ischemia-reperfusion injury in chronic kidney disease.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2014Article
- Effects of voluntary wheel running on the kidney at baseline and after ischaemia-reperfusion-induced acute kidney injury: a strain difference comparison.The Journal of physiology · 2013Article
- Exercise ameliorates renal cell apoptosis in chronic kidney disease by intervening in the intrinsic and the extrinsic apoptotic pathways in a rat model.Evidence-based complementary and alternative medicine : eCAM · 2013Article
- Sexual dimorphism: the aging kidney, involvement of nitric oxide deficiency, and angiotensin II overactivity.The journals of gerontology. Series A, Biological sciences and medical sciences · 2012Review
- Sodium nitrite de-stiffening of large elastic arteries with aging: role of normalization of advanced glycation end-products.Experimental gerontology · 2012Article
- Sexual dimorphism in development of kidney damage in aging Fischer-344 rats.Gender medicine · 2012Article
- Oxidative stress promotes hypertension and albuminuria during the autoimmune disease systemic lupus erythematosus.Hypertension (Dallas, Tex. : 1979) · 2012Article
- Exercise and diseased kidneys: are they compatible?The Journal of physiology · 2011Article
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4 authors at 2 institutions in 1 country.
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Abstract
The ageing kidney exhibits slowly developing chronic kidney disease (CKD) and is associated with nitric oxide (NO) deficiency and increased oxidative stress. The impact of exercise on the ageing kidney is not well understood. Here, we determined whether 12 weeks of treadmill exercise can influence age-dependent CKD in old (22-24 months) Fisher 344 (F344) male rats by comparing sedentary (SED) and exercise (EX) trained rats; young (3 months) rats were also studied. In addition to renal structure and function, we assessed protein levels of various isoforms of the NO synthases (NOS) and superoxide dismutase (SOD) enzymes as well as markers of oxidative stress, in kidney cortex and medulla. Renal function as determined by plasma creatinine, proteinuria, and glomerular structural injury worsened with age and was unaffected by exercise. Ageing also increased the protein abundance of neuronal NOSβ and p22phox while decreasing extracellular (EC) and copper/zinc (CuZn) SOD, in kidney cortex and medulla. H(2)O(2) content and nitrotyrosine abundance also increased in the kidney with age. None of these age-related changes were altered with exercise. However, exercise did increase renal cortical endothelial (e)NOS and EC SOD in young rats. Data indicate that exercise-induced increases in eNOS and EC SOD seen in young rats are lost with age. We conclude that chronic exercise is ineffective in reversing age-dependent CKD in the male F344 rat.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.