ArticleJournal of cell science2011
Pulsatile patterns of pituitary hormone gene expression change during development.
Article in Journal of cell science, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 31 citations in OpenAlex.
- Prolactin Secretion During Postnatal Development in Artificial Rearing Rats (Rattus norvegicus).Developmental neurobiology · 2025Article
- Intra-pituitary follicle-stimulating hormone signaling regulates hepatic lipid metabolism in mice.Nature communications · 2023Article
- Transcription Factor Pit-1 Affects Transcriptional Timing in the Dual-Promoter Human Prolactin Gene.Endocrinology · 2021Article
- Calcium dynamics and chromatin remodelling underlie heterogeneity in prolactin transcription.Journal of molecular endocrinology · 2021Article
- Cloning and mutagenetic modification of the firefly luciferase gene and its use for bioluminescence microscopy ofBiochemistry and biophysics reports · 2020Article
- A Darwinian and Physical Look at Stem Cell Biology Helps Understanding the Role of Stochasticity in Development.Frontiers in cell and developmental biology · 2020Article
- The role of beta cell heterogeneity in islet function and insulin release.Journal of molecular endocrinology · 2018Review
- Prolactinoma through the female life cycle.Endocrine · 2018Review
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- Article
- Role of Estrogen Response Element in the Human Prolactin Gene: Transcriptional Response and Timing.Molecular endocrinology (Baltimore, Md.) · 2016Article
- It is time to take timing seriously in clinical genetics.European journal of human genetics : EJHG · 2015Article
- A stochastic transcriptional switch model for single cell imaging data.Biostatistics (Oxford, England) · 2015Article
- Roles of connexins and pannexins in (neuro)endocrine physiology.Cellular and molecular life sciences : CMLS · 2015Review
- Clocks for all seasons: unwinding the roles and mechanisms of circadian and interval timers in the hypothalamus and pituitary.The Journal of endocrinology · 2014Review
- The prolactin gene: a paradigm of tissue-specific gene regulation with complex temporal transcription dynamics.Journal of neuroendocrinology · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
Important questions in biology have emerged recently concerning the timing of transcription in living cells. Studies on clonal cell lines have shown that transcription is often pulsatile and stochastic, with implications for cellular differentiation. Currently, information regarding transcriptional activity at cellular resolution within a physiological context remains limited. To investigate single-cell transcriptional activity in real-time in living tissue we used bioluminescence imaging of pituitary tissue from transgenic rats in which luciferase gene expression is driven by a pituitary hormone gene promoter. We studied fetal and neonatal pituitary tissue to assess whether dynamic patterns of transcription change during tissue development. We show that gene expression in single cells is highly pulsatile at the time endocrine cells first appear but becomes stabilised as the tissue develops in early neonatal life. This stabilised transcription pattern might depend upon tissue architecture or paracrine signalling, as isolated cells, generated from enzymatic dispersion of the tissue, display pulsatile luminescence. Nascent cells in embryonic tissue also showed coordinated transcription activity over short distances further indicating that cellular context is important for transcription activity. Overall, our data show that cells alter their patterns of gene expression according to their context and developmental stage, with important implications for cellular differentiation.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.