← Statins × cardiovascular events

SynthesisCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2011

Efficacy of statins for primary prevention in people at low cardiovascular risk: a meta-analysis.

Marcello Tonelli et al.PubMed ↗Full text ↗Publisher ↗

What the trial testedrandomised · 80,711 people · 2011

Randomised comparison

Reduced deaths

−10%−16% to −3%

Bigger than 3 in 10 for all-cause mortality

As reported

RR 0.90, 95% CI 0.84–0.97 · the paper's word: All-cause mortality

Randomised comparison

Reduced cardiovascular events

−36%−51% to −16%

Bigger than 8 in 10 for cardiovascular events

As reported

RR 0.64, 95% CI 0.49–0.84

Randomised comparison

Reduced cardiovascular events

−19%−32% to −4%

Bigger than 4 in 10 for cardiovascular events

As reported

RR 0.81, 95% CI 0.68–0.96

Three numbers in the abstract

the abstract, start to end

… than among controls (relative risk [RR] 0.90, 95% confidence interval [CI] …

… have nonfatal myocardial infarction (RR 0.64, 95% CI 0.49-0.84) and nonfatal stroke (RR 0.81, 95% CI 0.68-0.96).

← favours treatmentfavours comparator →
could be chance
All-cause mortality
RR 0.900.84–0.97
Cardiovascular events
RR 0.640.49–0.84
Cardiovascular events
RR 0.810.68–0.96
StatinsCardiovascular eventsAll-cause mortality

Statins × cardiovascular eventshelps?replicated

unlikelylikely
0.86not counted

Statins × all-cause mortalityhelps?mixed

unlikelylikely
0.50not counted
← favours treatmentfavours comparator →
more certainless certain
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