ArticleBMC medical genetics2011
SLCO1B1 rs4149056 polymorphism associated with statin-induced myopathy is differently distributed according to ethnicity in the Brazilian general population: Amerindians as a high risk ethnic group.
Article in BMC medical genetics, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 2 of them syntheses that pooled it.
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Who cites it
25 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Association of SLCO1B1 genetic variants with neonatal hyperbilirubinemia: a consolidated analysis of 36 studies.BMC pediatrics · 2025Pooled it
- Association Between SLCO1B1 Gene T521C Polymorphism and Statin-Related Myopathy Risk: A Meta-Analysis of Case-Control Studies.Medicine · 2015Pooled it
- SACRED: Effect of simvastatin on hepatic decompensation and death in subjects with high-risk compensated cirrhosis: Statins and Cirrhosis: Reducing Events of Decompensation.Contemporary clinical trials · 2021Trial
- CYP2B6 rs2279343 polymorphism is associated with smoking cessation success in bupropion therapy.European journal of clinical pharmacology · 2015Trial
- Analysis of the association betweenFrontiers in cardiovascular medicine · 2026Article
- Unveiling hidden risks: pharmacogenetic insights from a cross-sectional study of statin therapy in the Indian population.Pharmacological reports : PR · 2025Article
- Effect of Genetic Variations in Drug-Metabolizing Enzymes and Drug Transporters on the Pharmacokinetics of Rifamycins: A Systematic Review.Pharmacogenomics and personalized medicine · 2022Review
- [Diagnostics and treatment of statin-associated muscle symptoms].Der Internist · 2021Review
- Influence of Single Nucleotide Polymorphisms on Rifampin Pharmacokinetics in Tuberculosis Patients.Antibiotics (Basel, Switzerland) · 2020Review
- Pharmacogenetics of Statin-Induced Myotoxicity.Frontiers in genetics · 2020Review
- An African-specific profile of pharmacogene variants for rosuvastatin plasma variability: limited role for SLCO1B1 c.521T>C and ABCG2 c.421A>C.The pharmacogenomics journal · 2019Article
- Cholinergic receptor nicotinic alpha 5 subunit polymorphisms are associated with smoking cessation success in women.BMC medical genetics · 2018Article
- Article
- Frequencies of single-nucleotide polymorphisms and haplotypes of the SLCO1B1 gene in selected populations of the western balkans.Balkan journal of medical genetics : BJMG · 2015Article
- SLCO1B1 polymorphism is not associated with risk of statin-induced myalgia/myopathy in a Czech population.Medical science monitor : international medical journal of experimental and clinical research · 2015Article
- CHRNA4 rs1044396 is associated with smoking cessation in varenicline therapy.Frontiers in genetics · 2015Article
- The MYLIP p.N342S polymorphism is associated with response to lipid-lowering therapy in Brazilian patients with familial hypercholesterolemia.Pharmacogenetics and genomics · 2014Article
- Frequencies of two functionally significant SNPs and their haplotypes of organic anion transporting polypeptide 1B1 SLCO1B1 gene in six ethnic groups of Pakistani population.Iranian journal of basic medical sciences · 2014Article
- LPA rs10455872 polymorphism is associated with coronary lesions in Brazilian patients submitted to coronary angiography.Lipids in health and disease · 2014Article
- Prevalence of genetic variants associated with cardiovascular disease risk and drug response in the Southern Indian population of Kerala.Indian journal of human genetics · 2014Article
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7 authors.
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Abstract
backgroundRecent studies reported the association between SLCO1B1 polymorphisms and the development of statin-induced myopathy. In the scenario of the Brazilian population, being one of the most heterogeneous in the world, the main aim here was to evaluate SLCO1B1 polymorphisms according to ethnic groups as an initial step for future pharmacogenetic studies.
methodsOne hundred and eighty-two Amerindians plus 1,032 subjects from the general urban population were included. Genotypes for the SLCO1B1 rs4149056 (c.T521C, p.V174A, exon 5) and SLCO1B1 rs4363657 (g.T89595C, intron 11) polymorphisms were detected by polymerase chain reaction followed by high resolution melting analysis with the Rotor Gene 6000® instrument.
resultsThe frequencies of the SLCO1B1 rs4149056 and rs4363657 C variant allele were higher in Amerindians (28.3% and 26.1%) and were lower in African descent subjects (5.7% and 10.8%) compared with Mulatto (14.9% and 18.2%) and Caucasian descent (14.8% and 15.4%) ethnic groups (p<0.001 and p<0.001, respectively). Linkage disequilibrium analysis show that these variant alleles are in different linkage disequilibrium patterns depending on the ethnic origin.
conclusionOur findings indicate interethnic differences for the SLCO1B1 rs4149056 C risk allele frequency among Brazilians. These data will be useful in the development of effective programs for stratifying individuals regarding adherence, efficacy and choice of statin-type.
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