ArticleObesity surgery2011
Studies in insulin resistance following very low calorie diet and/or gastric bypass surgery.
Article in Obesity surgery, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Commercial Very Low Energy Meal Replacements for Preoperative Weight Loss in Obese Patients: a Systematic Review.Obesity surgery · 2016Pooled it
- Effects of RYGB on energy expenditure, appetite and glycaemic control: a randomized controlled clinical trial.International journal of obesity (2005) · 2016Trial
- Bariatric Surgery: Targeting pancreatic β cells to treat type II diabetes.Frontiers in endocrinology · 2023Review
- Bariatric Surgery and Type 1 Diabetes: Unanswered Questions.Frontiers in endocrinology · 2020Review
- The Effects of Bariatric Surgery on Islet Function, Insulin Secretion, and Glucose Control.Endocrine reviews · 2019Review
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- Article
- Metabolic syndrome and the hepatorenal reflex.Surgical neurology international · 2016Review
- Metabolic syndrome and the hepatorenal reflex.Surgical neurology international · 2016Review
- Gastric inhibitory polypeptide (GIP) is selectively decreased in the roux-limb of dietary obese mice after RYGB surgery.PloS one · 2015Article
- Aberrant liver insulin receptor isoform a expression normalises with remission of type 2 diabetes after gastric bypass surgery.PloS one · 2015Article
- Liver ENPP1 protein increases with remission of type 2 diabetes after gastric bypass surgery.BMC gastroenterology · 2014Article
- Can medical therapy mimic the clinical efficacy or physiological effects of bariatric surgery?International journal of obesity (2005) · 2014Review
- Acute improvement in insulin resistance after laparoscopic Roux-en-Y gastric bypass: is 3 days enough to correct insulin metabolism?Obesity surgery · 2013Article
- Effects of bariatric surgery on glucose homeostasis and type 2 diabetes.Gastroenterology · 2012Review
- Mechanisms of improved glycaemic control after Roux-en-Y gastric bypass.Diabetologia · 2012Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The explanation for the rapid improvement in insulin resistance after Roux-en Y gastric bypass (RYGB) may involve mechanisms additional to caloric restriction and improvements in peripheral glucose disposal. 8 severely obese patients underwent a 6-day very low calorie diet (VLCD) (456 kcal/day) followed 1-3 weeks later by RYGB. Insulin resistance was measured by short intravenous insulin tolerance test (IVITT) and by homeostasis model assessment (HOMA) before and again 6 days after the VLCD and after RYGB. In a group of 24 matched patients, HOMA assessments were made before and six days after RYGB. HOMA-IR fell significantly from 6.84.9 to 4.32.9 (p < 0.05) following VLCD, but this was less than the subsequent fall following RYGB (6.8 ± 4.9 to 1.50.4, p < 0.01). Control patients who underwent RYGB alone, reduced their HOMA-IR to 1.50.9 following the operation which was not significantly different from the VLCD then RYGB group. Following VLCD, IVITT showed no significant change. However, 6 days after RYGB, IVITT showed worsened insulin induced glucose uptake (p < 0.05). Patients undergoing VLCD over six days had a reduction in HOMA-IR which was half that of patients undergoing RYGB. Patients who underwent both VLCD and RYGB had a total reduction in HOMA similar to those who underwent the RYGB alone. In contrast, IVITT showed a worsening in insulin induced glucose disposal following RYGB, which suggests worsening peripheral insulin resistance. This study supports the hypothesis that mechanisms other than caloric restriction are involved in the acute improvement in HOMA-IR following RYGB.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.