ArticleBMC nephrology2011
The relationships between exogenous and endogenous antioxidants with the lipid profile and oxidative damage in hemodialysis patients.
Article in BMC nephrology, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 57 citations in OpenAlex.
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- Potential harms of supplementation with high doses of antioxidants in athletes.Journal of exercise science and fitness · 2022Review
- Adaptive Response of Thermophiles to Redox Stress and Their Role in the Process of dye Degradation From Textile Industry Wastewater.Frontiers in physiology · 2022Review
- Association of serum lycopene concentrations with all-cause and cardiovascular mortality among individuals with chronic kidney disease: A cohort study.Frontiers in nutrition · 2022Article
- Herbal antioxidants in dialysis patients: a review of potential mechanisms and medical implications.Renal failure · 2021Review
- Dietary patterns associated with renal impairment in the Northern Ireland Cohort for the Longitudinal Study of Ageing (NICOLA).European journal of nutrition · 2021Observational
- Moderators of the Impact of (Poly)Phenols Interventions on Psychomotor Functions and BDNF: Insights from Subgroup Analysis and Meta-Regression.Nutrients · 2020Review
- Risk factors for restless legs syndrome in hemodialysis patients in Taiwan: A case-control study.Medicine · 2019Observational
- Serum xanthophyll carotenoids are associated with estimated glomerular filtration rate in an aged cohort.Scientific reports · 2019Article
- Mitochondria as a Source and a Target for Uremic Toxins.International journal of molecular sciences · 2019Review
- Carotenoids and Markers of Oxidative Stress in Human Observational Studies and Intervention Trials: Implications for Chronic Diseases.Antioxidants (Basel, Switzerland) · 2019Review
- The association between high-density lipoproteins and estimated glomerular filtration rate in patients without severe kidney disease.International urology and nephrology · 2018Article
- Oxidative Stress and Nonalcoholic Fatty Liver Disease in Hemodialysis Patients.BioMed research international · 2018Article
- Alterations in conformational state of albumin in plasma in chronic hemodialyzed patients.PloS one · 2018Article
- Oxidative stress during erythropoietin hyporesponsiveness anemia at end stage renal disease: Molecular and biochemical studies.Journal of advanced research · 2016Article
- The activity of antioxidant enzymes in blood platelets in different types of renal replacement therapy: a cross-sectional study.International urology and nephrology · 2016Article
- Lycopene and kidney; future potential application.Journal of nephropharmacology · 2015Article
- Relationship between inflammation and oxidative stress and cognitive decline in the institutionalized elderly.Oxidative medicine and cellular longevity · 2015Article
Corrections and comments
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Authors and funding
13 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe sought to investigate the relationships among the plasma levels of carotenoids, tocopherols, endogenous antioxidants, oxidative damage and lipid profiles and their possible effects on the cardiovascular risk associated with hemodialysis (HD) patients.
methodsThe study groups were divided into HD and healthy subjects. Plasma carotenoid, tocopherol and malondialdehyde (MDA) levels, as well as erythrocyte reduced glutathione (GSH), were measured by HPLC. Blood antioxidant enzymes, kidney function biomarkers and the lipid profiles were analyzed by spectrophotometric methods.
resultsPlasma lycopene levels and blood glutathione peroxidase (GPx) activity were significantly decreased in HD patients compared with healthy subjects. Total cholesterol, low-density lipoprotein cholesterol (LDL-c), creatinine, urea, MDA, GSH, superoxide dismutase (SOD) and catalase (CAT) were significantly increased in HD (p < 0.05). Lycopene levels were correlated with MDA (r = -0.50; p < 0.01), LDL-c (r = -0.38; p = 0.01) levels, the LDL-c/HDL-c index (r = -0.33; p = 0.03) and GPx activity (r = 0.30; p = 0.03). Regression models showed that lycopene levels were correlated with LDL-c (β estimated = -31.59; p = 0.04), while gender was correlated with the TC/HDL-c index and triglycerides. Age did not present a correlation with the parameters evaluated. GPx activity was negatively correlated with MDA levels and with the LDL-c/HDL-c and CT/HDL-c indexes.
conclusionsLycopene may represent an additional factor that contributes to reduced lipid peroxidation and atherogenesis in hemodialysis patients.
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Registered trials
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