ReviewJournal of genetics and genomics = Yi chuan xue bao2011
Cell competition and its implications for development and cancer.
Review in Journal of genetics and genomics = Yi chuan xue bao, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
35 citing papers in PubMed, 69 citations in OpenAlex.
- Article
- Article
- E2F1 mediates competition, proliferation and response to cisplatin in cohabitating resistant and sensitive ovarian cancer cells.Frontiers in oncology · 2024Article
- Ribonucleotide reductase regulatory subunit M2 drives glioblastoma TMZ resistance through modulation of dNTP production.Science advances · 2023Article
- The Double-Edged Proteins in Cancer Proteomes and the Generation of Induced Tumor-Suppressing Cells (iTSCs).Proteomes · 2023Review
- Three unconventional maxims in the natural selection of cancer cells: Generation of induced tumor-suppressing cells (iTSCs).International journal of biological sciences · 2023Review
- Polyploidy in development and tumor models in Drosophila.Seminars in cancer biology · 2022Review
- Active elimination of intestinal cells drives oncogenic growth in organoids.Cell reports · 2021Article
- Article
- Proteotoxic stress is a driver of the loser status and cell competition.Nature cell biology · 2021Article
- Article
- The Initial Stage of Tumorigenesis in Drosophila Epithelial Tissues.Advances in experimental medicine and biology · 2019Review
- Endorsing cellular competitiveness in aberrant epithelium of oral submucous fibrosis progression: neighbourhood analysis of immunohistochemical attributes.Histochemistry and cell biology · 2018Article
- Endoreplication: The Good, the Bad, and the Ugly.Trends in cell biology · 2018Review
- Cell Extrusion: A Stress-Responsive Force for Good or Evil in Epithelial Homeostasis.Developmental cell · 2018Review
- Learning on the Fly: The Interplay between Caspases and Cancer.BioMed research international · 2018Review
- Chronic activation of JNK JAK/STAT and oxidative stress signalling causes the loser cell status.Nature communications · 2017Article
- Possible roles of mechanical cell elimination intrinsic to growing tissues from the perspective of tissue growth efficiency and homeostasis.PLoS computational biology · 2017Article
- Development of an optimized synthetic Notch receptor as an in vivo cell-cell contact sensor.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Tissue-Intrinsic Tumor Hotspots: Terroir for Tumorigenesis.Trends in cancer · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cell competition is a struggle for existence between cells in heterogeneous tissues of multicellular organisms. Loser cells, which die during cell competition, are normally viable when grown only with other loser cells, but when mixed with winner cells, they are at a growth disadvantage and undergo apoptosis. Intriguingly, several recent studies have revealed that cells bearing mutant tumor-suppressor genes, which show overgrowth and tumorigenesis in a homotypic situation, are frequently eliminated, through cell competition, from tissues in which they are surrounded by wild-type cells. Here, we focus on the regulation of cellular competitiveness and the mechanism of cell competition as inferred from two different categories of mutant cells: (1) slower-growing cells and (2) structurally defective cells. We also discuss the possible role of cell competition as an intrinsic homeostasis system through which normal cells sense and remove aberrant cells, such as precancerous cells, to maintain the integrity and normal development of tissues and organs.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.