Evidence map›Paper›PMID 22040838›Full record

ArticleDiabetes care2012

Independent and combined effects of exercise training and metformin on insulin sensitivity in individuals with prediabetes.

Steven K Malin, Robert Gerber, Stuart R Chipkin, Barry Braun

Registry-linked trialAbstract readControlled Clinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes care, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03355469 (Exercise Dose and Metformin for Vascular Health in Adults With Metabolic Syndrome), which is not on this map. Cited by 122 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
122citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03355469 phase2 / phase3completedstarted 2017, after this paper: background citation

Exercise Dose and Metformin for Vascular Health in Adults With Metabolic Syndrome

Ran2017Enrolled91Registered outcomes6Posted comparisons36ConditionsMetabolic SyndromeArmsHigh intensity exercise, Low intensity exercise, Metformin, Placebo
PMID 26583801PMID 11300445PMID 16115299PMID 23505172PMID 24947027PMID 18340209PMID 17785362PMID 16682488PMID 16644702PMID 18955635PMID 19487636PMID 19567533other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

122 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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62 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Steven K MalinEnergy Metabolism Laboratory, Department of Kinesiology, University of Massachusetts, Amherst, Massachusetts, USA. bbraun@kin.umass.edu
Robert Gerber
Stuart R Chipkin
Barry Braun

Funding

NIDDK NIH HHS 5-R56-DK-081038NIDDK NIH HHS R56 DK081038
6 · The paper itself

Abstract

objectivePhysical activity or metformin enhances insulin sensitivity and opposes the progression from prediabetes to type 2 diabetes. The combination may be more effective because each treatment stimulates AMP-activated protein kinase activity in skeletal muscle. We evaluated the effects of exercise training plus metformin on insulin sensitivity in men and women with prediabetes, compared with each treatment alone. RESEARCH DESIGN AND

methodsFor 12 weeks, men and women with prediabetes were assigned to the following groups: placebo (P), 2,000 mg/day metformin (M), exercise training with placebo (EP), or exercise training with metformin (EM) (n = 8 per group). Before and after the intervention, insulin sensitivity was measured by euglycemic hyperinsulinemic (80 mU/m(2)/min) clamp enriched with [6,6-(2)H]glucose. Changes due to intervention were compared across groups by repeated-measures ANOVA.

resultsAll three interventions increased insulin sensitivity (P < 0.05) relative to the control group. The mean rise was 25-30% higher after EP than after either EM or M, but this difference was not significant.

conclusionsInsulin sensitivity was considerably higher after 12 weeks of exercise training and/or metformin in men and women with prediabetes. Subtle differences among condition means suggest that adding metformin blunted the full effect of exercise training.

Indexed as

Insulin ResistanceAdultAMP-Activated Protein KinasesBlood GlucoseDiabetes Mellitus, Type 2Double-Blind MethodExerciseFemaleGlucose Clamp TechniqueHumansLife StyleMaleMetforminMiddle AgedPrediabetic StateAMP-Activated Protein KinasesBlood GlucoseMetformin

Identifiers

PMID22040838
PMCPMC3241331

What Socratic holds

Texttitle and abstract
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.