ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2011
Fast-activating voltage- and calcium-dependent potassium (BK) conductance promotes bursting in pituitary cells: a dynamic clamp study.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed.
- Erg currents support electrical bursting in murine anterior pituitary corticotrophs.The Journal of physiology · 2026Article
- On the role of L-type Ca2+ and BK channels in a biophysical model of cartwheel interneurons.PLoS computational biology · 2026Article
- Identifying and investigating emergent behaviour in neural systems.Frontiers in neuroscience · 2026Article
- Long-term, Dynamic Remodelling of the Corticotroph Transcriptome and Excitability After a Period of Chronic Stress.Endocrinology · 2024Article
- Conversion of spikers to bursters in pituitary cell networks: Is it better to disperse for maximum exposure or circle the wagons?PLoS computational biology · 2024Article
- Sex differences in pituitary corticotroph excitability.Frontiers in physiology · 2023Article
- Sodium-mediated plateau potentials in an identified decisional neuron contribute to feeding-related motor pattern genesis inFrontiers in neural circuits · 2023Article
- Modeling pulsativity in the hypothalamic-pituitary-adrenal hormonal axis.Scientific reports · 2022Article
- Classification of bursting patterns: A tale of two ducks.PLoS computational biology · 2022Review
- Network Properties of Electrically Coupled Bursting Pituitary Cells.Frontiers in endocrinology · 2022Article
- Robust spike timing in an excitable cell with delayed feedback.Journal of the Royal Society, Interface · 2021Article
- The Mechanisms Underlying Autonomous Adrenocorticotropic Hormone Secretion in Cushing's Disease.International journal of molecular sciences · 2020Review
- Ion channel noise shapes the electrical activity of endocrine cells.PLoS computational biology · 2020Article
- Article
- Activation of a nucleotide-dependent RCK domain requires binding of a cation cofactor to a conserved site.eLife · 2019Article
- Action potential propagation and synchronisation in myelinated axons.PLoS computational biology · 2019Article
- A computational model for gonadotropin releasing cells in the teleost fish medaka.PLoS computational biology · 2019Article
- Mathematical Modelling of Endocrine Systems.Trends in endocrinology and metabolism: TEM · 2019Review
- Role of glucocorticoid negative feedback in the regulation of HPA axis pulsatility.Stress (Amsterdam, Netherlands) · 2018Review
- Common and diverse elements of ion channels and receptors underlying electrical activity in endocrine pituitary cells.Molecular and cellular endocrinology · 2018Review
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Authors and funding
5 authors.
Funding
Abstract
The electrical activity pattern of endocrine pituitary cells regulates their basal secretion level. Rat somatotrophs and lactotrophs exhibit spontaneous bursting and have high basal levels of hormone secretion, while gonadotrophs exhibit spontaneous spiking and have low basal hormone secretion. It has been proposed that the difference in electrical activity between bursting somatotrophs and spiking gonadotrophs is due to the presence of large conductance potassium (BK) channels on somatotrophs but not on gonadotrophs. This is one example where the role of an ion channel type may be clearly established. We demonstrate here that BK channels indeed promote bursting activity in pituitary cells. Blocking BK channels in bursting lacto-somatotroph GH4C1 cells changes their firing activity to spiking, while further adding an artificial BK conductance via dynamic clamp restores bursting. Importantly, this burst-promoting effect requires a relatively fast BK activation/deactivation, as predicted by computational models. We also show that adding a fast-activating BK conductance to spiking gonadotrophs converts the activity of these cells to bursting. Together, our results suggest that differences in BK channel expression may underlie the differences in electrical activity and basal hormone secretion levels among pituitary cell types and that the rapid rate of BK channel activation is key to its role in burst promotion.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.