ArticleCardiorenal medicine2011
Prenatal Programming and Epigenetics in the Genesis of the Cardiorenal Syndrome.
Article in Cardiorenal medicine, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 30 citations in OpenAlex.
- Non-linear associations and threshold effects of oxidative balance score and composite dietary antioxidant index on frailty risk in patients with cardiovascular-kidney-metabolic syndrome.Frontiers in nutrition · 2025Article
- Epigenetics: a potential key mechanism involved in the pathogenesis of cardiorenal syndromes.Journal of nephrology · 2018Review
- Birth weight and body mass index z-score in childhood brain tumors: A cross-sectional study.Scientific reports · 2018Article
- Gestational Nutrition and the Family Stone.Integrative medicine (Encinitas, Calif.) · 2017Article
- The potential role of biomarkers in predicting gestational diabetes.Endocrine connections · 2016Review
- Epigenetic and developmental influences on the risk of obesity, diabetes, and metabolic syndrome.Diabetes, metabolic syndrome and obesity : targets and therapy · 2015Review
- Advances in the pathogenesis of cardiorenal syndrome type 3.Oxidative medicine and cellular longevity · 2015Review
- The pathophysiology of hypertension in patients with obesity.Nature reviews. Endocrinology · 2014Review
- Emerging biomarkers and metabolomics for assessing toxic nephropathy and acute kidney injury (AKI) in neonatology.BioMed research international · 2014Review
- Hypertension in children and adolescents attending a lipid clinic.European journal of pediatrics · 2013Article
- Roles of melatonin in fetal programming in compromised pregnancies.International journal of molecular sciences · 2013Article
- Influence of race, ethnicity and socioeconomic status on kidney disease.Nature reviews. Nephrology · 2012Review
- Fetal stress and programming of hypoxic/ischemic-sensitive phenotype in the neonatal brain: mechanisms and possible interventions.Progress in neurobiology · 2012Review
- Mitochondria and Oxidative Stress in the Cardiorenal Metabolic Syndrome.Cardiorenal medicine · 2012Article
- Gestational Diabetes and the Offspring: Implications in the Development of the Cardiorenal Metabolic Syndrome in Offspring.Cardiorenal medicine · 2012Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
Abstract
The presence of a group of interacting maladaptive factors, including hypertension, insulin resistance, metabolic dyslipidemia, obesity, and microalbuminuria and/or reduced renal function, collectively constitutes the cardiorenal metabolic syndrome (CRS). Nutritional and other environmental cues during fetal development can permanently affect the composition, homeostatic systems, and functions of multiple organs and systems; this process has been referred to as 'programming'. Since the original formulation of the notion that low birth weight is a proxy for 'prenatal programming' of adult hypertension and cardiovascular disease, evidence has also emerged for programming of kidney disease, insulin resistance, obesity, metabolic dyslipidemia, and other chronic diseases. The programming concept was initially predicated on the notion that in utero growth restriction due to famine was responsible for increased hypertension, and cardiovascular and renal diseases. On the other hand, we are now more commonly exposed to increasing rates of maternal obesity. The current review will discuss the overarching role of maternal overnutrition, as well as fetal undernutrition, in epigenetic programming in relation to the pathogenesis of the CRS in children and adults.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.