ArticleThe Journal of physiology2012
Action potential-triggered somatic exocytosis in mesencephalic trigeminal nucleus neurons in rat brain slices.
Article in The Journal of physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- CaNeuroscience bulletin · 2026Article
- A Central Somatic Transmission Mediates Proprioceptive Facilitation of Muscle Pain.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Search for unknown neural link between the masticatory and cognitive brain systems to clarify the involvement of its impairment in the pathogenesis of Alzheimer's disease.Frontiers in cellular neuroscience · 2024Review
- CaProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Beyond plasticity: the dynamic impact of electrical synapses on neural circuits.Nature reviews. Neuroscience · 2019Review
- Veratridine modifies the gating of human voltage-gated sodium channel Nav1.7.Acta pharmacologica Sinica · 2018Article
- Effect of amyloids on the vesicular machinery: implications for somatic neurotransmission.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Temporal components of cholinergic terminal to dopaminergic terminal transmission in dorsal striatum slices of mice.The Journal of physiology · 2014Article
- Label-free dopamine imaging in live rat brain slices.ACS chemical neuroscience · 2014Article
- Brainstem neurons survive the identical ischemic stress that kills higher neurons: insight to the persistent vegetative state.PloS one · 2014Article
- Extrasynaptic exocytosis and its mechanisms: a source of molecules mediating volume transmission in the nervous system.Frontiers in physiology · 2012Article
- The dynamics of somatic exocytosis in monoaminergic neurons.Frontiers in physiology · 2012Article
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Authors and funding
16 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neurons in the mesencephalic trigeminal nucleus (MeV) play essential roles in proprioceptive sensation of the face and oral cavity. The somata of MeV neurons are generally assumed to carry out neuronal functions but not to play a direct role in synaptic transmission. Using whole-cell recording and membrane capacitance (C(m)) measurements, we found that the somata of MeV neurons underwent robust exocytosis (C(m) jumps) upon depolarization and with the normal firing of action potentials in brain slices. Both removing [Ca(2+)](o) and buffering [Ca(2+)](i) with BAPTA blocked this exocytosis, indicating that it was completely Ca(2+) dependent. In addition, an electron microscopic study showed synaptic-like vesicles approximated to the plasma membrane in somata. There was a single Ca(2+)-dependent releasable vesicle pool with a peak release rate of 1912 fF s(-1). Importantly, following depolarization-induced somatic exocytosis, GABA-mediated postsynaptic currents were transiently reduced by 31%, suggesting that the somatic vesicular release had a retrograde effect on afferent GABAergic transmission. These results provide strong evidence that the somata of MeV neurons undergo robust somatic secretion and may play a crucial role in bidirectional communication between somata and their synaptic inputs in the central nervous system.
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