Evidence map›Paper›PMID 22151826›Full record

ArticlePediatric diabetes2012

Feasibility of prolonged continuous glucose monitoring in toddlers with type 1 diabetes.

Eva Tsalikian, Larry Fox, Stuart Weinzimer, Bruce Buckingham, Neil H White, Roy Beck, Craig Kollman, Dongyuan Xing, Katrina Ruedy, Diabetes Research in Children Network Study Group

Registry-linked trialOpen access · greenAbstract readMulticenter Study
In one paragraph

Article in Pediatric diabetes, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02912728 (Strategies to Enhance New CGM Use in Early Childhood), which is not on this map. Cited by 41 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
41citing papers in PubMed, 5 pooled it
2.9field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02912728 nacompletednot on this mapstarted 2017, after this paper: background citation

Strategies to Enhance New CGM Use in Early Childhood: A Randomized Clinical Trial to Assess the Efficacy and Safety of Continuous Glucose Monitoring in Youth < 8 With Type 1 Diabetes

TypeinterventionalSponsorJaeb Center for Health ResearchRan2017 to 2019Enrolled143ConditionsType 1 Diabetes MellitusArmsCGM + Family Behavioral Intervention, Standard CGM
3 · Its place in the literature

Who cites it

41 citing papers in PubMed, 5 syntheses or guidelines pooled it, 83 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 1 country.

Eva TsalikianPediatric Endocrinology and Diabetes, University of Iowa, Iowa City, IA 52242, USA. direcnet@jaeb.org
Larry Fox
Stuart Weinzimer
Bruce Buckingham
Neil H White
Roy Beck
Craig Kollman
Dongyuan Xing
Katrina Ruedy
Diabetes Research in Children Network Study Group
Jaeb Center for Health Research · USNemours Children’s Clinic · USStanford University · USUniversity of Iowa · USWashington University in St. Louis · USYale University · US

Funding

Cooperative Multicenter Diabetes Research Network for Hypoglycemia PreventionU10HD041890 · NICHD · JAEB CENTER FOR HEALTH RESEARCH, INC. · PI BECK, ROY W. · 2007 to 2011
$9.7M
Career Development Programs in Diabetes Research for Pediatrics EndocrinologistsK12DK094714 · NIDDK · YALE UNIVERSITY · PI TAMBORLANE, WILLIAM V · 2011 to 2020
$4.3M
Coordinating Center: Glucose Sensors in Type I DiabetesU01HD041890 · NICHD · JAEB CENTER FOR HEALTH RESEARCH, INC. · PI BECK, ROY W · 2001 to 2006
$4.1M
Yale Study of Closed-Loop Automated Glucose Control for Hypoglycemia PreventionU10HD041906 · NICHD · YALE UNIVERSITY · PI WEINZIMER, STUART ALAN · 2001 to 2011
$3.6M
Prevention of Nocturnal Hypoglycemia: Effect on Neurologic Outcome in ToddlersU10HD041908 · NICHD · STANFORD UNIVERSITY · PI BUCKINGHAM, BRUCE A · 2001 to 2011
$3.5M
Prevention of Hypoglycemia and Associated Complications in Type 1 DiabetesU10HD041915 · NICHD · UNIVERSITY OF IOWA · PI TSALIKIAN, EVA · 2001 to 2011
$3.4M
Hypoglycemia in Children and Adolescents with T1DM: Mechanisms and PreventionU10HD041918 · NICHD · NEMOURS CHILDREN'S CLINIC · PI MAURAS, NELLY · 2001 to 2011
$3.1M
Diabetes Research in Children Network (DirecNet)U10HD056526 · NICHD · WASHINGTON UNIVERSITY · PI WHITE, NEIL H. · 2007 to 2011
$1.4M
NICHD NIH HHS HD41890-10NICHD NIH HHS HD41906-10NICHD NIH HHS HD41908-10NICHD NIH HHS HD41915NICHD NIH HHS HD41918NICHD NIH HHS HD56526NICHD NIH HHS U01 HD041890NICHD NIH HHS U10 HD041890NICHD NIH HHS U10 HD041906NICHD NIH HHS U10 HD041908NICHD NIH HHS U10 HD041915NICHD NIH HHS U10 HD041918NICHD NIH HHS U10 HD056526NIDDK NIH HHS K12 DK094714
6 · The paper itself

Abstract

objectiveTo examine the feasibility of continuous glucose monitoring (CGM) use in very young children with type 1 diabetes (T1D). RESEARCH DESIGN AND

methodsTwenty-three children less than 4 yr of age with T1D were provided with a FreeStyle Navigator(®) (n = 21) or a Paradigm(®) (n = 2) CGM device. At baseline, mean age was 3.0 ± 0.8 yr, mean hemoglobin A1c (HbA1c) was 8.0 ± 0.8%, 10 were using an insulin pump and 13 were on multiple daily injections. CGM use was evaluated over a 6-month period.

resultsThree children dropped out of the study before the end of 6 months. Among the 20 children who completed 6 months of follow-up, CGM use in month 6 was ≥6 d/wk in 9 (45%), 4 ≤ 6 d/wk in 2 (10%), and <4 d/wk in 9 (45%). Skin reactions were minimal. Although there was no detectable change in mean HbA1c between baseline and 6 months (7.9 and 8.0%, respectively), there was a high degree of parental satisfaction with CGM as measured on the CGM satisfaction scale questionnaire. A high percentage of glucose values were in the hyperglycemic range, and biochemical hypoglycemia was infrequent.

conclusionMore than 40% of very young children were able to safely use CGM on a near-daily basis after 6 months. CGM demonstrated frequent hyperglycemic excursions, with a large variability in glucose readings. Although improvement in glycemic control was not detected in the group as a whole, parental satisfaction with CGM was high.

Indexed as

Blood Glucose Self-MonitoringBlood GlucoseChild, PreschoolDiabetes Mellitus, Type 1Feasibility StudiesFemaleGlycated HemoglobinHumansHypoglycemiaInfantMaleParentsPatient SatisfactionBlood GlucoseGlycated Hemoglobin

Identifiers

PMID22151826
PMCPMC3665108
OpenAlexW2156728006

What Socratic holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.