ArticleThe Journal of clinical investigation1979
Transport of very low density lipoprotein triglycerides in varying degrees of obesity and hypertriglyceridemia.
Article in The Journal of clinical investigation, 1979. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
44 citing papers in PubMed, 289 citations in OpenAlex.
- Insulin therapy in burn patients does not contribute to hepatic triglyceride production.The Journal of clinical investigation · 1998Trial
- Beta-blockade lowers peripheral lipolysis in burn patients receiving growth hormone. Rate of hepatic very low density lipoprotein triglyceride secretion remains unchanged.Annals of surgery · 1996Trial
- Abnormalities in very low, low and high density lipoproteins in hypertriglyceridemia. Reversal toward normal with bezafibrate treatment.The Journal of clinical investigation · 1984Trial
- The metabolic syndrome-insulin resistance index: a tool for identifying dyslipidemia across varied glucose metabolic score in patients with cardiovascular disease.Frontiers in endocrinology · 2025Article
- Predicting the 10-year incidence of dyslipidemia based on novel anthropometric indices, using data mining.Lipids in health and disease · 2024Article
- The role of Huidouba in regulating skeletal muscle metabolic disorders in prediabetic mice through AMPK/PGC-1α/PPARα pathway.Diabetology & metabolic syndrome · 2023Article
- A Positive Association between the Atherogenic Index of Plasma and White Matter Hyperintensity.Korean journal of family medicine · 2022Article
- Day-night rhythm of skeletal muscle metabolism is disturbed in older, metabolically compromised individuals.Molecular metabolism · 2020Article
- Intravenous Insulin Versus Conservative Management in Hypertriglyceridemia-Associated Acute Pancreatitis.Journal of the Endocrine Society · 2020Article
- Modern prevalence of the Fredrickson-Levy-Lees dyslipidemias: findings from the Very Large Database of Lipids and National Health and Nutrition Examination Survey.Archives of medical science : AMS · 2020Article
- Pathogenesis of Lipid Disorders in Insulin Resistance: a Brief Review.Current diabetes reports · 2018Review
- Quinoa Seed Lowers Serum Triglycerides in Overweight and Obese Subjects: A Dose-Response Randomized Controlled Clinical Trial.Current developments in nutrition · 2017Article
- Leptin Levels Are Higher in Whole Compared to Skim Human Milk, Supporting a Cellular Contribution.Nutrients · 2016Article
- Evaluation of CETP activity in vivo under non-steady-state conditions: influence of anacetrapib on HDL-TG flux.Journal of lipid research · 2016Article
- Adipose tissue and metabolic syndrome: too much, too little or neither.European journal of clinical investigation · 2015Review
- Extract of Ginkgo Biloba Ameliorates Streptozotocin-Induced Type 1 Diabetes Mellitus and High-Fat Diet-Induced Type 2 Diabetes Mellitus in Mice.International journal of medical sciences · 2015Article
- Kinetic Studies to Elucidate Impaired Metabolism of Triglyceride-rich Lipoproteins in Humans.Frontiers in physiology · 2015Review
- Pathway-selective insulin resistance and metabolic disease: the importance of nutrient flux.The Journal of biological chemistry · 2014Review
- Dyslipidaemia in hypertensive obese type 2 diabetic patients in Jamaica.Archives of medical science : AMS · 2010Article
- Decrease in hepatic very-low-density lipoprotein-triglyceride secretion after weight loss is inversely associated with changes in circulating leptin.Diabetes, obesity & metabolism · 2010Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Measurements of transport of triglycerides (TG) in very low density lipoproteins (VLDL) were carried out in 59 patients by injection of radioactive glycerol, determinations of specific activities of VLDL-TG for 48 h thereafter, and treatment of the data by multicompartmental analysis. The patients were divided into three groups: normal weight (89-120% ideal weight), mildly obese (120-135% ideal weight), and markedly obese (135% ideal weight). They had varying levels of VLDL-TG ranging from normal to markedly elevated. In many subjects, there was a positive correlation between concentrations and transport of VLDL indicating that overproduction of VLDL-TG contributed to hypertriglyceridemia. In others, and particularly in several markedly obese subjects, transport rates were greatly increased without significant hypertriglyceridemia, suggesting that they had enhanced capacity to clear TG. In all groups, however, there were patients whose degree of hypertriglyceridemia seemed out of proportion to their transport rates. This finding and the fact that many patients have increased secretion of VLDL-TG without elevated plasma TG suggests that both overproduction of VLDL-TG and insufficient enhancement of clearance contributed to the development of hypertriglyceridemia.The data showed a poor correlation between transport rates determined by our multicompartment analysis and single-exponential analysis used previously by other investigators (r = 0.46); this comparison was not improved by segregating patients according to their degree of obesity. Although two conversion pathways (fast and slow synthetic paths) were required to fit the data, there was no correlation between transport rates and the ratio of the two pathways. Also, despite the known pathway of conversion of VLDL to low density lipoprotein, no correlation was found between VLDL-TG transport rates and estimated low density lipoprotein-cholesterol concentrations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.