ArticleHuman molecular genetics2012
β1D chain increases α7β1 integrin and laminin and protects against sarcolemmal damage in mdx mice.
Article in Human molecular genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
26 citing papers in PubMed, 32 citations in OpenAlex.
- Extracellular matrix in skeletal muscle injury and atrophy: mechanisms and therapeutic implications.Journal of orthopaedic translation · 2025Review
- Massage protects skeletal muscle from injury during long-term heavy-duty exercise via integrin β1 and laminin 2 channels of basement membrane.BMC complementary medicine and therapies · 2023Article
- Sarcospan increases laminin-binding capacity of α-dystroglycan to ameliorate DMD independent of Galgt2.Human molecular genetics · 2022Article
- Review
- Thrombospondin-3 augments injury-induced cardiomyopathy by intracellular integrin inhibition and sarcolemmal instability.Nature communications · 2019Article
- Alterations in the muscle force transfer apparatus in aged rats during unloading and reloading: impact of microRNA-31.The Journal of physiology · 2018Article
- Loss of mouse cardiomyocyte talin-1 and talin-2 leads to β-1 integrin reduction, costameric instability, and dilated cardiomyopathy.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Age-related Differences in Dystrophin: Impact on Force Transfer Proteins, Membrane Integrity, and Neuromuscular Junction Stability.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- αAmerican journal of physiology. Cell physiology · 2017Article
- Deletion of the Ste20-like kinase SLK in skeletal muscle results in a progressive myopathy and muscle weakness.Skeletal muscle · 2017Article
- Article
- Sarcospan Regulates Cardiac Isoproterenol Response and Prevents Duchenne Muscular Dystrophy-Associated Cardiomyopathy.Journal of the American Heart Association · 2015Article
- Deletion of integrin α7 subunit does not aggravate the phenotype of laminin α2 chain-deficient mice.Scientific reports · 2015Article
- Effects of aging, exercise, and disease on force transfer in skeletal muscle.American journal of physiology. Endocrinology and metabolism · 2015Review
- Sarcospan integration into laminin-binding adhesion complexes that ameliorate muscular dystrophy requires utrophin and α7 integrin.Human molecular genetics · 2015Article
- Resistance exercise increases active MMP and β1-integrin protein expression in skeletal muscle.Physiological reports · 2014Article
- Integrins and integrin-associated proteins in the cardiac myocyte.Circulation research · 2014Review
- Integrins protect cardiomyocytes from ischemia/reperfusion injury.The Journal of clinical investigation · 2013Article
- The potential of sarcospan in adhesion complex replacement therapeutics for the treatment of muscular dystrophy.The FEBS journal · 2013Review
- The cell biology of disease: cellular and molecular mechanisms underlying muscular dystrophy.The Journal of cell biology · 2013Review
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
The dystrophin-glycoprotein complex connects myofibers with extracellular matrix laminin. In Duchenne muscular dystrophy, this linkage system is absent and the integrity of muscle fibers is compromised. One potential therapy for addressing muscular dystrophy is to augment the amount of α7β1 integrin, the major laminin-binding integrin in skeletal muscle. Whereas transgenic over-expression of α7 chain may alleviate development of muscular dystrophy and extend the lifespan of severely dystrophic mdx/utrn(-/-) mice, further enhancing levels of α7 chain provided little additional membrane integrin and negligible additional improvement in mdx mice. We demonstrate here that normal levels of β1 chain limit formation of integrin heterodimer and that increasing β1D chain in mdx mice results in more functional integrin at the sarcolemma, more matrix laminin and decreased damage of muscle fibers. Moreover, increasing the amount of β1D chain in vitro enhances transcription of α7 integrin and α2 laminin genes and the amounts of these proteins. Thus manipulation of β1D integrin expression offers a novel approach to enhance integrin-mediated therapy for muscular dystrophy.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.