ArticleCurrent cardiovascular risk reports2012
Perivascular Fat and the Microcirculation: Relevance to Insulin Resistance, Diabetes, and Cardiovascular Disease.
Article in Current cardiovascular risk reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The role of cocoa flavanols in modulating peripheral and cerebral microvascular function in healthy individuals and populations at-risk of cardiovascular disease: a systematic review.Nutrition journal · 2025Pooled it
- Temporal Dissociation of Impaired Glucose Tolerance, Adipose Lipid Remodeling and Endothelial Dysfunction in Aorta After HFD Withdrawal.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2026Article
- The Effect of Overweight/Obesity on Cutaneous Microvascular Reactivity as Measured by Laser-Doppler Fluxmetry: A Systematic Review.Biomedicines · 2024Review
- Peri-Carotid Adipose Tissue and Atherosclerosis at Carotid Bifurcation.Journal of cardiovascular development and disease · 2024Article
- The Role of Perivascular Adipose Tissue in the Pathogenesis of Endothelial Dysfunction in Cardiovascular Diseases and Type 2 Diabetes Mellitus.Biomedicines · 2023Review
- Keeping It Local in Metabolic Disease: Adipose Tissue Paracrine Signaling and Insulin Resistance.Diabetes · 2022Review
- Skeletal Muscle Microvascular Dysfunction in Obesity-Related Insulin Resistance: Pathophysiological Mechanisms and Therapeutic Perspectives.International journal of molecular sciences · 2022Review
- Peripheral Vascular Abnormalities in Anorexia Nervosa: A Psycho-Neuro-Immune-Metabolic Connection.International journal of molecular sciences · 2021Review
- Paracardial fat remodeling affects systemic metabolism through alcohol dehydrogenase 1.The Journal of clinical investigation · 2021Article
- Microvascular Dysfunction in Diabetes Mellitus and Cardiometabolic Disease.Endocrine reviews · 2021Review
- Microvascular Phenotyping in the Maastricht Study: Design and Main Findings, 2010-2018.American journal of epidemiology · 2020Observational
- Mechanisms linking adipose tissue inflammation to cardiac hypertrophy and fibrosis.Clinical science (London, England : 1979) · 2019Review
- Insulin Receptor Substrate 2 Controls Insulin-Mediated Vasoreactivity and Perivascular Adipose Tissue Function in Muscle.Frontiers in physiology · 2018Article
- Functional Characterization of Preadipocytes Derived from Human Periaortic Adipose Tissue.International journal of endocrinology · 2017Article
- Browning of White Fat: Novel Insight Into Factors, Mechanisms, and Therapeutics.Journal of cellular physiology · 2017Review
- Monitoring and management of hypertension with obesity in adolescents.Integrated blood pressure control · 2017Review
- The impact of insulin resistance on the kidney and vasculature.Nature reviews. Nephrology · 2016Review
- Brown adipose tissue: The heat is on the heart.American journal of physiology. Heart and circulatory physiology · 2016Review
- Role of the Renal Microcirculation in Progression of Chronic Kidney Injury in Obesity.American journal of nephrology · 2016Review
- Association of Adipokines with Insulin Resistance, Microvascular Dysfunction, and Endothelial Dysfunction in Healthy Young Adults.Mediators of inflammation · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type 2 diabetes and its major risk factor, obesity, are a growing burden for public health. The mechanisms that connect obesity and its related disorders, such as insulin resistance, type 2 diabetes, and hypertension, are still undefined. Microvascular dysfunction may be a pathophysiologic link between insulin resistance and hypertension in obesity. Many studies have shown that adipose tissue-derived substances (adipokines) interact with (micro)vascular function and influence insulin sensitivity. In the past, research focused on adipokines from perivascular adipose tissue (PVAT). In this review, we focus on the interactions between adipokines, predominantly from PVAT, and microvascular function in relation to the development of insulin resistance, diabetes, and cardiovascular disease.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.