Evidence map›Paper›PMID 22277145›Full record

ArticleJournal of clinical hypertension (Greenwich, Conn.)2012

The role of nutraceutical supplements in the treatment of dyslipidemia.

Mark Houston

Open access · bronzeAbstract read
In one paragraph

Article in Journal of clinical hypertension (Greenwich, Conn.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.6field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 46 citations in OpenAlex.

  1. Metabolic Disease Management through Natural Products: A Thorough Exploration.Endocrine, metabolic & immune disorders drug targets · 2025
    Article
  2. Frontiers in nutrition · 2023
    Review
  3. Review
  4. Article
  5. Review
  6. Article
  7. Review
  8. Resveratrol for protection against statin toxicity in C2C12 and H9c2 cells.Journal of biochemical and molecular toxicology · 2020
    Article
  9. Review
  10. Article
  11. Management of Statin Intolerance in 2018: Still More Questions Than Answers.American journal of cardiovascular drugs : drugs, devices, and other interventions · 2018
    Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Mark HoustonFrom the Department of Medicine, Vanderbilt University School of Medicine.
Vanderbilt University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The combination of a lipid-lowering diet and scientifically proven nutraceutical supplements has the ability to significantly reduce low-density lipoprotein (LDL) cholesterol, increase LDL particle size, decrease LDL particle number, lower trigylcerides and very LDL levels, and increase total and high-density lipoprotein 2b cholesterol. In addition, inflammation, oxidative stress, and immune responses are decreased. In several prospective clinical trials, coronary heart disease and cardiovascular disease have been reduced with many nutraceutical supplements. This nutritional and nutraceutical supplement treatment is a valid alternative for patients who are intolerant to statins, cannot take other drugs for the treatment of dyslipidemia, or prefer alternative treatments. This new approach to lipid management to decrease vascular disease utilizes a functional medicine approach with a broader treatment program that will address the multitude of steps involved in lipid-induced vascular damage.

Indexed as

Dietary SupplementsAtherosclerosisDietary FatsDyslipidemiasHumansLipoproteinsLipoproteins, VLDLOxidative StressPantetheineResveratrolStilbenesTocotrienolsTriglyceridesVascular DiseasesVasodilator AgentsDietary FatsLipoproteinsLipoproteins, VLDLPantetheinepantethineResveratrolStilbenesTocotrienolsTriglyceridesVasodilator Agents

Identifiers

PMID22277145
PMCPMC9645405
OpenAlexW1570369031

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.