ArticleMagnetic resonance in medicine2012
Model-based mapping of fat unsaturation and chain length by chemical shift imaging--phantom validation and in vivo feasibility.
Article in Magnetic resonance in medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07178145 (MRI of Epicardial Adipose Tissue Composition), which is not on this map. Cited by 30 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
MRI of Epicardial Adipose Tissue Composition: Development of Methods and Application to Heart Failure With Preserved Ejection Fraction
Who cites it
30 citing papers in PubMed, 68 citations in OpenAlex.
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- Chemical shift encoding based double bonds quantification in triglycerides using deep image prior.Quantitative imaging in medicine and surgery · 2025Article
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- Imaging-based assessment of fatty acid composition in human bone marrow adipose tissue at 7 T: Method comparison and in vivo feasibility.Magnetic resonance in medicine · 2023Article
- Feasibility of joint mapping of triglyceride saturation and water longitudinal relaxation in a single breath hold applied to high fat-fraction adipose depots in the periclavicular anatomy.Magnetic resonance imaging · 2023Article
- Favorable fatty acid composition in adipose tissue in healthy Iraqi- compared to Swedish-born men - a pilot study using MRI assessment.Adipocyte · 2022Article
- Accelerated fatty acid composition MRI of epicardial adipose tissue: Development and application to eplerenone treatment in a mouse model of obesity-induced coronary microvascular disease.Magnetic resonance in medicine · 2022 · on this mapArticle
- Bilateral gradient-echo spectroscopic imaging with correction of frequency variations for measurement of fatty acid composition in mammary adipose tissue.Magnetic resonance in medicine · 2021Article
- Mapping of fatty acid composition with free-breathing MR spectroscopic imaging and compressed sensing.NMR in biomedicine · 2021Article
- Feasibility of Hepatic Fat Quantification Using Proton Density Fat Fraction by Multi-Echo Chemical-Shift-Encoded MRI at 7T.Frontiers in physics · 2021Article
- Generalized parameter estimation in multi-echo gradient-echo-based chemical species separation.Quantitative imaging in medicine and surgery · 2020Article
- An investigation into the effect of body mass index on the agreement between whole-body fat mass determined by MRI and air-displacement plethysmography.The British journal of radiology · 2019Article
- Differentiating supraclavicular from gluteal adipose tissue based on simultaneous PDFF and TJournal of magnetic resonance imaging : JMRI · 2019 · on this mapArticle
- Fat spectral modeling on triglyceride composition quantification using chemical shift encoded magnetic resonance imaging.Magnetic resonance imaging · 2018Article
- Sources of systematic error in proton density fat fraction (PDFF) quantification in the liver evaluated from magnitude images with different numbers of echoes.NMR in biomedicine · 2018Article
- Article
- Bone marrow fat content in 70 adolescent girls with anorexia nervosa: Magnetic resonance imaging and magnetic resonance spectroscopy assessment.Pediatric radiology · 2017Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Knowledge about the triglyceride (fat) (1)H spectrum enables quantitative determination of several triglyceride characteristics. This work describes a model-based chemical shift imaging method that separates water and fat signal and provides maps of three triglyceride quantities: fatty acid carbon chain length, unsaturation degree, and polyunsaturation degree. The method was validated by imaging a phantom containing 10 different oils using 1.5 and 3.0 T clinical scanners, with gas-liquid chromatography as reference. Repeated acquisitions demonstrated high reproducibility of the method. Statistical tests of correlation and linear regression were performed to examine the accuracy of the method. Significant correlation was found at both field strengths for all three quantities, and high correlation (r(2) > 0.95) was found for measuring unsaturation degree and polyunsaturation degree. Feasibility of the method for in vivo imaging of the thigh was demonstrated at both field strengths. The estimates of unsaturation degree and polyunsaturation degree in subcutaneous adipose tissue were in agreement with literature values, while chain length appeared over estimated. The method has potential use in large-scale cross-sectional and longitudinal studies of triglyceride composition, and its relation to diet and various diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.