ArticleJournal of psychiatric research2012
Structural brain abnormalities and suicidal behavior in borderline personality disorder.
Article in Journal of psychiatric research, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 71 papers, 6 of them syntheses that pooled it.
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Who cites it
71 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Characterizing brain structural and functional abnormalities in borderline personality disorder by seed-based d mapping approach.Brain imaging and behavior · 2026Pooled it
- Hemispheric asymmetries in borderline personality disorder: a systematic review.European archives of psychiatry and clinical neuroscience · 2025Pooled it
- Neural correlates of aggression in personality disorders from the perspective of DSM-5 maladaptive traits: a systematic review.Translational psychiatry · 2023Pooled it
- Functional alterations of the suicidal brain: a coordinate-based meta-analysis of functional imaging studies.Brain imaging and behavior · 2022Pooled it
- Default mode network and frontolimbic gray matter abnormalities in patients with borderline personality disorder: A voxel-based meta-analysis.Scientific reports · 2016Pooled it
- Joint and distinct neural structure and function deficits in major depressive disorder with suicidality: a multimodal meta-analysis of MRI studies.Journal of psychiatry & neuroscience : JPNPooled it
- Magnetoencephalographic Correlates of Suicidal Ideation in Major Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2020Trial
- Treatment-related topological reorganization of the structural connectome in major depressive disorder with suicidal ideation.BMC psychiatry · 2026Article
- Specific frontostriatal structural alterations underlie emotional instability but not inattention in ADHD and healthy individuals.Journal of psychiatry & neuroscience : JPN · 2026Article
- An explainable multimodal artificial intelligence model for classifying suicide attempters with borderline personality disorder: a pilot study.Scientific reports · 2025Article
- Multimodal Machine Learning Prediction of 12-Month Suicide Attempts in Bipolar Disorder.Bipolar disorders · 2025Article
- Neurobiological correlates of personality dimensions in borderline personality disorder using graph analysis of functional connectivity.Scientific reports · 2025Article
- Impact of Comorbid Personality Disorder on the Risk of Involuntary Hospitalization in Patients Referred for Urgent Forensic Assessment: A Cross-Sectional Study.Brain sciences · 2024Article
- Identifying behaviour-related and physiological risk factors for suicide attempts in the UK Biobank.Nature human behaviour · 2024Article
- Characterizing the temporal dynamics of intrinsic brain activities in depressed adolescents with prior suicide attempts.European child & adolescent psychiatry · 2024Article
- Targeting suicidal ideation in major depressive disorder with MRI-navigated Stanford accelerated intelligent neuromodulation therapy.Translational psychiatry · 2024Article
- Abnormal Brain Circuits Characterize Borderline Personality and Mediate the Relationship between Childhood Traumas and Symptoms: A mCCA+jICA and Random Forest Approach.Sensors (Basel, Switzerland) · 2023Article
- Machine learning based identification of structural brain alterations underlying suicide risk in adolescents.Discover mental health · 2023Article
- History of suicide attempts associated with the thinning right superior temporal gyrus among individuals with schizophrenia.Brain imaging and behavior · 2022Article
- Aberrant Structural Connectivity of the Triple Network System in Borderline Personality Disorder Is Associated with Behavioral Dysregulation.Journal of clinical medicine · 2022Article
11 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundStructural brain abnormalities have been demonstrated in subjects with BPD in prefrontal and fronto-limbic regions involved in the regulation of emotion and impulsive behavior, executive cognitive function and episodic memory. Impairment in these cognitive functions is associated with increased vulnerability to suicidal behavior. We compared BPD suicide attempters and non-attempters, high and low lethality attempters to healthy controls to identify neural circuits associated with suicidal behavior in BPD.
methodsStructural MRI scans were obtained on 68 BPD subjects (16 male, 52 female), defined by IPDE and DIB/R criteria, and 52 healthy controls (HC: 28 male, 24 female). Groups were compared by diagnosis, attempt status, and attempt lethality. ROIs were defined for areas reported to have structural or metabolic abnormalities in BPD, and included: mid-inf. orbitofrontal cortex, mid-sup temporal cortex, anterior cingulate, insula, hippocampus, amygdala, fusiform, lingual and parahippocampal gyri. Data were analyzed using optimized voxel-based morphometry implemented with DARTEL in SPM5, co-varied for age and gender, corrected for cluster extent (p < .001).
resultsCompared to HC, BPD attempters had significantly diminished gray matter concentrations in 8 of 9 ROIs, non-attempters in 5 of 9 ROIs. Within the BPD sample, attempters had diminished gray matter in Lt. insula compared to non-attempters. High lethality attempters had significant decreases in Rt. mid-sup. temporal gyrus, Rt. mid-inf. orbitofrontal gyrus, Rt. insular cortex, Lt. fusiform gyrus, Lt. lingual gyrus and Rt. parahippocampal gyrus compared to low lethality attempters.
conclusionsSpecific structural abnormalities discriminate BPD attempters from non-attempters and high from low lethality attempters.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.