Evidence map›Paper›PMID 22347369›Full record

Trial reportPloS one2012

Massage therapy for osteoarthritis of the knee: a randomized dose-finding trial.

Adam I Perlman, Ather Ali, Valentine Yanchou Njike, David Hom, Anna Davidi, Susan Gould-Fogerite, Carl Milak, David L Katz

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 44 papers, 6 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 6 pooled it
6.9field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00970008 phase2completednot on this map

Exploring Massage Benefits for Arthritis of the Knee

TypeinterventionalSponsorUniversity of Medicine and Dentistry of New JerseyRan2009 to 2011Enrolled125ConditionsOsteoarthritis of the KneeArmsMassage 30 min 2x/wk x4 wks then 1x/wk x4 wks, Massage 60 min 2x/wk for 4 wks then 1x/wk for 4 wks, Massage 30 min sessions 1x/wk for 8 wks, Massage 60 min session 1x/wk for 8 wks
NCT01537484 nacompletednot on this map

Multisite RCT Investigating the Efficacy of Massage in Osteoarthritis

TypeinterventionalSponsorDuke UniversityRan2012 to 2015Enrolled222ConditionsOsteoarthritisArmsMassage Therapy
3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 6 syntheses or guidelines pooled it, 117 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Adam I PerlmanDuke Integrative Medicine, Duke University School of Medicine, Durham, North Carolina, United States of America. adam.perlman@duke.edu
Ather Ali
Valentine Yanchou Njike
David Hom
Anna Davidi
Susan Gould-Fogerite
Carl Milak
David L Katz
Rutgers, The State University of New Jersey · USYale Griffin Prevention Research Center · USYale University · USDuke University · US

Funding

MULTISITE RCT INVESTIGATING THE EFFICACY OF MASSAGE IN OSTEOARTHRITISR01AT004623 · NCCIH · UNIV OF MED/ DENT OF NJ-SCH/HLTH REL PRO · PI PERLMAN, ADAM I. · 2009 to 2015
$4.6M
NCCIH NIH HHS L30 AT004887NCCIH NIH HHS R01 AT004623
6 · The paper itself

Abstract

backgroundIn a previous trial of massage for osteoarthritis (OA) of the knee, we demonstrated feasibility, safety and possible efficacy, with benefits that persisted at least 8 weeks beyond treatment termination.

methodsWe performed a RCT to identify the optimal dose of massage within an 8-week treatment regimen and to further examine durability of response. Participants were 125 adults with OA of the knee, randomized to one of four 8-week regimens of a standardized Swedish massage regimen (30 or 60 min weekly or biweekly) or to a Usual Care control. Outcomes included the Western Ontario and McMaster Universities Arthritis Index (WOMAC), visual analog pain scale, range of motion, and time to walk 50 feet, assessed at baseline, 8-, 16-, and 24-weeks.

resultsWOMAC Global scores improved significantly (24.0 points, 95% CI ranged from 15.3-32.7) in the 60-minute massage groups compared to Usual Care (6.3 points, 95% CI 0.1-12.8) at the primary endpoint of 8-weeks. WOMAC subscales of pain and functionality, as well as the visual analog pain scale also demonstrated significant improvements in the 60-minute doses compared to usual care. No significant differences were seen in range of motion at 8-weeks, and no significant effects were seen in any outcome measure at 24-weeks compared to usual care. A dose-response curve based on WOMAC Global scores shows increasing effect with greater total time of massage, but with a plateau at the 60-minute/week dose.

conclusionGiven the superior convenience of a once-weekly protocol, cost savings, and consistency with a typical real-world massage protocol, the 60-minute once weekly dose was determined to be optimal, establishing a standard for future trials.

trial registrationClinicalTrials.gov NCT00970008.

Indexed as

AgedFeasibility StudiesFemaleHumansMaleMassageMiddle AgedOsteoarthritis, KneePain MeasurementRange of Motion, ArticularTime FactorsTreatment OutcomeWalking

Identifiers

PMID22347369
PMCPMC3275589
OpenAlexW2012705424

What Socratic holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.