ArticleAnnals of neurology2012
Middle cerebral artery intraplaque hemorrhage: prevalence and clinical relevance.
Article in Annals of neurology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 101 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Trial of PCSK9 Inhibition in Patients with Acute Stroke and Symptomatic Intracranial Atherosclerosis - a Prospective, Randomized, Open-label, Blinded End-point Study with High-resolution MR Vessel Wall Imaging
Stroke Imaging Package Study
Stroke Imaging Package Study of Intracranial Atherosclerosis
Who cites it
101 citing papers in PubMed, 3 syntheses or guidelines pooled it, 172 citations in OpenAlex.
- Intracranial atherosclerotic plaque features on vessel wall imaging predict first ever and recurrence of stroke: a meta-analysis.European radiology · 2025Pooled it
- Imaging endpoints of intracranial atherosclerosis using vessel wall MR imaging: a systematic review.Neuroradiology · 2021Pooled it
- Vessel Wall Magnetic Resonance Imaging Biomarkers of Symptomatic Intracranial Atherosclerosis: A Meta-Analysis.Stroke · 2021Pooled it
- Association between basilar artery configuration and Vessel Wall features: a prospective high-resolution magnetic resonance imaging study.BMC medical imaging · 2019Trial
- Diagnostic utility of high-resolution magnetic resonance vessel wall imaging for identifying culprit plaques in intracranial atherosclerotic disease.Frontiers in neurology · 2026Article
- High-Resolution Magnetic Resonance Imaging Radiomics for Identifying High-Risk Intracranial Plaques.Translational stroke research · 2025Article
- Atherosclerotic plaque evolution predicts cerebral ischemic events in patients with intracranial atherosclerosis: a multicentre longitudinal study using high-resolution MRI.European radiology · 2025Article
- Vessel wall imaging of vertebrobasilar artery configurations associated with posterior circulation infarction and high-risk atherosclerotic plaques.Scientific reports · 2025Article
- Association between ischemic stroke and hyperintense plaques detected by high-resolution vessel wall MRI in Japanese patients with intracranial atherosclerotic disease.Frontiers in stroke · 2025Article
- Design of the "EAST" strategy in patients with symptomatic intracranial atherosclerotic stenosis.Frontiers in neurology · 2025Article
- High-resolution magnetic resonance imaging features of time-of-flight magnetic resonance angiography signal loss and its relevance to ischemic stroke.Quantitative imaging in medicine and surgery · 2024Article
- 7T-high resolution MRI-derived radiomic analysis for the identification of symptomatic intracranial atherosclerotic plaques.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2024Article
- A bibliometric analysis of the 100 most-cited clinical articles in the research of intracranial artery stenosis and intracranial atherosclerosis.Surgical neurology international · 2024Review
- Panvascular concept in the evaluation and treatment of intracranial atherosclerotic stenosis.Frontiers in neurology · 2024Review
- Quantitative radiomics analysis of imaging features in adults and children Mycoplasma pneumonia.Frontiers in medicine · 2024Article
- Vessel Wall Imaging of Intracranial Arteries: Fundamentals and Clinical Applications.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2023Review
- A Non-Linear Role of Hyperlipidemia on Progression of Intracranial Atherosclerotic Plaques and Acute Downstream Ischemic Events.Journal of atherosclerosis and thrombosis · 2023Article
- The Role of High-Resolution Magnetic Resonance Imaging in Cerebrovascular Disease: A Narrative Review.Brain sciences · 2023Review
- High-resolution vessel wall magnetic resonance imaging in intracranial vasculopathies: an experience from eastern India.The British journal of radiology · 2023Article
- Plaque characteristics after endovascular treatment in patients with intracranial atherosclerotic disease.Chinese neurosurgical journal · 2022Article
41 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveLittle is known about the composition of middle cerebral artery (MCA) plaques and how they relate to clinical status. Using high-resolution magnetic resonance imaging (HR-MRI), we aimed to examine the occurrence of high signal on T1-weighted fat-suppressed images (HST1) of MCA plaques, which are highly suggestive of fresh or recent intraplaque hemorrhage.
methodsWe retrospectively analyzed the HR-MRI and clinical data of 107 adult patients with high-grade (>70%) MCA stenosis. On HR-MRI, HST1 within an MCA plaque was defined as an area with an intensity >150% of the signal of adjacent muscles. The relationship between HST1 and clinical presentations was analyzed.
resultsA total of 109 stenotic MCAs (46 symptomatic and 63 asymptomatic) on 981 image slices were analyzed. HST1 was revealed on HR-MRI in 11 vessels (10.1%, 9 symptomatic and 2 asymptomatic). The occurrence rate of HST1 between symptomatic and asymptomatic MCAs was significantly different (19.6% vs 3.2%, p = 0.01).
interpretationHST1 within MCA plaque on HR-MRI is associated with ipsilateral stroke. Our results provide new insight into the vascular biology of MCA atherosclerosis.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.