ArticleG3 (Bethesda, Md.)2012
Genome-wide association mapping of quantitative traits in outbred mice.
Article in G3 (Bethesda, Md.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 50 citations in OpenAlex.
- Celebrating discovery across the tree of life.G3 (Bethesda, Md.) · 2023Article
- NADCells · 2022Review
- Genetics of murine type 2 diabetes and comorbidities.Mammalian genome : official journal of the International Mammalian Genome Society · 2022Review
- The impact of genetic background on mouse models of kidney disease.Kidney international · 2022Review
- Prediction performance of linear models and gradient boosting machine on complex phenotypes in outbred mice.G3 (Bethesda, Md.) · 2022Article
- Integrative Analyses RevealCells · 2021Article
- Article
- A large-scale genome-lipid association map guides lipid identification.Nature metabolism · 2020Article
- Using Genetic and Species Diversity to Tackle Kidney Disease.Trends in genetics : TIG · 2020Review
- NADNature reviews. Nephrology · 2020Review
- GnRH-1 Neural Migration From the Nose to the Brain Is Independent From Slit2, Robo3 and NELL2 Signaling.Frontiers in cellular neuroscience · 2019Article
- Genetic Regulation of Plasma Lipid Species and Their Association with Metabolic Phenotypes.Cell systems · 2018Article
- Developmental nonlinearity drives phenotypic robustness.Nature communications · 2017Article
- A Bivariate Hypothesis Testing Approach for Mapping the Trait-Influential Gene.Scientific reports · 2017Article
- Heterogeneous Stock Populations for Analysis of Complex Traits.Methods in molecular biology (Clifton, N.J.) · 2017Article
- Loss of Kynurenine 3-Mono-oxygenase Causes Proteinuria.Journal of the American Society of Nephrology : JASN · 2016Article
- Multiple testing correction in linear mixed models.Genome biology · 2016Article
- A forest-based feature screening approach for large-scale genome data with complex structures.BMC genetics · 2015Article
- A permutation approach for selecting the penalty parameter in penalized model selection.Biometrics · 2015Article
- Lung necrosis and neutrophils reflect common pathways of susceptibility to Mycobacterium tuberculosis in genetically diverse, immune-competent mice.Disease models & mechanisms · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 4 institutions in 2 countries.
Funding
Abstract
Recent developments in high-density genotyping and statistical analysis methods that have enabled genome-wide association studies in humans can also be applied to outbred mouse populations. Increased recombination in outbred populations is expected to provide greater mapping resolution than traditional inbred line crosses, improving prospects for identifying the causal genes. We carried out genome-wide association mapping by using 288 mice from a commercially available outbred stock; NMRI mice were genotyped with a high-density single-nucleotide polymorphism array to map loci influencing high-density lipoprotein cholesterol, systolic blood pressure, triglyceride levels, glucose, and urinary albumin-to-creatinine ratios. We found significant associations (P < 10(-5)) with high-density lipoprotein cholesterol and identified Apoa2 and Scarb1, both of which have been previously reported, as candidate genes for these associations. Additional suggestive associations (P < 10(-3)) identified in this study were also concordant with published quantitative trait loci, suggesting that we are sampling from a limited pool of genetic diversity that has already been well characterized. These findings dampen our enthusiasm for currently available commercial outbred stocks as genetic mapping resources and highlight the need for new outbred populations with greater genetic diversity. Despite the lack of novel associations in the NMRI population, our analysis strategy illustrates the utility of methods that could be applied to genome-wide association studies in humans.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.