ArticleImmunogenetics2012
Evolution of the βGRP/GNBP/β-1,3-glucanase family of insects.
Article in Immunogenetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 67 citations in OpenAlex.
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- Role of microbial pesticides in pest control for lepidopteran: research status and prospect.Biotechnology letters · 2025Review
- Immune functions of pattern recognition receptors in Lepidoptera.Frontiers in immunology · 2023Review
- Efficient compartmentalization in insect bacteriomes protects symbiotic bacteria from host immune system.Microbiome · 2022Article
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- KPI5 Is Involved in the Regulation of the Expression of Antibacterial Peptide Genes and Hemolymph Melanization in the Silkworm,Frontiers in immunology · 2022Article
- Integration of dsRNA against host immune response genes augments the virulence of transgenic Metarhizium robertsii strains in insect pest species.Microbial biotechnology · 2021Article
- Phylogenetic analyses, protein modeling and active site prediction of two pathogenesis related (PR2 and PR3) genes from bread wheat.PloS one · 2021Article
- A subfamily roadmap of the evolutionarily diverse glycoside hydrolase family 16 (GH16).The Journal of biological chemistry · 2019Article
- Biochemical and Functional Characterization of Glycoside Hydrolase Family 16 Genes inFrontiers in physiology · 2019Article
- RNA interference-mediated silencing of genes involved in the immune responses of the soybean pod borerPeerJ · 2018Article
- The initial analysis of a serine proteinase gene (AccSp10) from Apis cerana cerana: possible involvement in pupal development, innate immunity and abiotic stress responses.Cell stress & chaperones · 2017Article
- Comparative genomic analysis of innate immunity reveals novel and conserved components in crustacean food crop species.BMC genomics · 2017Article
- Article
- Immune genes and divergent antimicrobial peptides in flies of the subgenus Drosophila.BMC evolutionary biology · 2016Article
- Comparative genomic study of arachnid immune systems indicates loss of beta-1,3-glucanase-related proteins and the immune deficiency pathway.Journal of evolutionary biology · 2016Article
- Initiating protease with modular domains interacts with β-glucan recognition protein to trigger innate immune response in insects.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The βGRP/GNBP/β-1,3-glucanase protein family of insects includes several proteins involved in innate immune recognition, such as the β-glucan recognition proteins of Lepidoptera and the Gram-negative bacteria-binding proteins of Drosophila. A phylogenetic analysis supported the existence of two distinct subfamilies, designated the pattern recognition receptor (PRR) and glucanase subfamilies, which originated by gene duplication prior to the origin of the Holometabola. In the C-terminal region (CTR) shared by both subfamilies, the PRR subfamily has evolved significantly more rapidly at the amino acid sequence level than has the glucanase subfamily, implying a relative lack of constraint on the amino acid sequence of this region in the PRR subfamily. PRR subfamily members also include an N-terminal region (NTR), involved in carbohydrate recognition, which is not shared by glucanase subfamily members. In comparisons between paralogous PRR subfamily members, there were no conserved amino acid residues in the NTR. However, when pairs of putatively orthologous PRR subfamily members were compared, the NTR was most often as conserved as the CTR or more so. This pattern suggests that the NTR may be important in functions specific to the different paralogs, while amino acid sequence changes in the NTR may have been important in functional differentiation among paralogs, specifically with regard to the types of carbohydrates that they recognize.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.