ArticleDiabetic medicine : a journal of the British Diabetic Association2012
Contemporary rates of severe hypoglycaemia in youth with type 1 diabetes: variability by insulin regimen.
Article in Diabetic medicine : a journal of the British Diabetic Association, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Drug-related risk of severe hypoglycaemia in observational studies: a systematic review and meta-analysis.BMC endocrine disorders · 2015Pooled it
- Managing Severe Hypoglycaemia in Patients with Diabetes: Current Challenges and Emerging Therapies.Diabetes, metabolic syndrome and obesity : targets and therapy · 2023Review
- Predictors of changing insulin dose requirements and glycaemic control in children, adolescents and young adults with Type 1 diabetes.Diabetic medicine : a journal of the British Diabetic Association · 2018Article
- Defining relevant hypoglycemia measures in children and adolescents with type 1 diabetes.Pediatric diabetes · 2018Review
- An Economic Evaluation of Continuous Glucose Monitoring for People with Type 1 Diabetes and Impaired Awareness of Hypoglycaemia within North West London Clinical Commissioning Groups in England.European endocrinology · 2017Article
- Influence of HbA1c and BMI on Lipid Trajectories in Youths and Young Adults With Type 1 Diabetes.Diabetes care · 2017Observational
- A decade of temporal trends in overweight/obesity in youth with type 1 diabetes after the Diabetes Control and Complications Trial.Pediatric diabetes · 2015Article
- Diabetes and epilepsy in children and adolescents.Current diabetes reports · 2015Review
- Reduced Worries of Hypoglycaemia, High Satisfaction, and Increased Perceived Ease of Use after Experiencing Four Nights of MD-Logic Artificial Pancreas at Home (DREAM4).Journal of diabetes research · 2015Article
- Article
- Intensively managed young children with type 1 diabetes consume high-fat, low-fiber diets similar to age-matched controls.Nutrition research (New York, N.Y.) · 2014Article
- A population-based study of risk factors for severe hypoglycaemia in a contemporary cohort of childhood-onset type 1 diabetes.Diabetologia · 2013Article
- Severe hypoglycemia in a juvenile diabetic rat model: presence and severity of seizures are associated with mortality.PloS one · 2013Article
- Quality of life and technology: impact on children and families with diabetes.Current diabetes reports · 2012Review
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
aimsTo determine incidence rates of severe hypoglycaemia and compare incidence rates by insulin regimen in a diverse sample of youth with Type 1 diabetes from two sites.
methodsIn this observational study, 255 youth (51% female) aged 9-15 years receiving varied insulin regimens provided data prospectively for a median of 1.2 years. Reported episodes of severe hypoglycaemia, defined as episodes requiring help from another person for oral treatment or episodes resulting in seizure/coma, and current insulin regimens were collected systematically. Incidence rates were calculated and compared according to insulin regimen in bivariate and multivariate analyses.
resultsAt first encounter, participants had a median age of 12.2 years (range 9.0-15.0), median diabetes duration of 4.4 years (range 1.0-13.0) and mean HbA(1c) of 67 ± 12 mmol/mol (8.3 ± 1.1%). The incidence rate was 37.6/100 patient-years for all severe hypoglycaemia and 9.6/100 patient-years for seizure/coma. The incidence rate for severe hypoglycaemia was 31.8/100 patient-years on continuous subcutaneous insulin infusion (pump therapy), 34.4/100 patient-years on basal-bolus injections and 46.1/100 patient-years on NPH (NPH vs. pump therapy: P = 0.04). The incidence rate for seizure/coma was 4.5/100 patient-years on pump therapy, 11.1/100 patient-years on basal-bolus injections and 14.4/100 patients-years on NPH (NPH vs. pump therapy: P = 0.004). In the multivariate analysis, the rate of seizure/coma was significantly higher for those on NPH vs. pump therapy (rate ratio 2.9, P = 0.03).
conclusionsRates of severe hypoglycaemia in youth with Type 1 diabetes remain high. Pump therapy was associated with lower rates of all severe hypoglycaemia and seizure/coma in comparison with NPH.
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