ArticleAmerican journal of physiology. Heart and circulatory physiology2012
Biaxial vasoactivity of porcine coronary artery.
Article in American journal of physiology. Heart and circulatory physiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Myocardial infarction impaired wall mechanics and hemodynamics in peripheral arteries.Frontiers in physiology · 2023Article
- Linking the region-specific tissue microstructure to the biaxial mechanical properties of the porcine left anterior descending artery.Acta biomaterialia · 2022Article
- The Role of Biaxial Loading on Smooth Muscle Contractility in the Nulliparous Murine Cervix.Annals of biomedical engineering · 2021Article
- [Experimental measurement and modeling analysis of active and passive mechanical properties of arterial vessel wall].Sheng wu yi xue gong cheng xue za zhi = Journal of biomedical engineering = Shengwu yixue gongchengxue zazhi · 2020Article
- Adipose-derived stromal cell secreted factors induce the elastogenesis cascade within 3D aortic smooth muscle cell constructs.Matrix biology plus · 2019Article
- Bifurcation Asymmetry of Small Coronary Arteries in Juvenile and Adult Mice.Frontiers in physiology · 2018Article
- Acute Tachycardia Increases Aortic Distensibility, but Reduces Total Arterial Compliance Up to a Moderate Heart Rate.Frontiers in physiology · 2018Article
- Passive and Active Triaxial Wall Mechanics in a Two-Layer Model of Porcine Coronary Artery.Scientific reports · 2017Article
- Microstructure-based constitutive model of coronary artery with active smooth muscle contraction.Scientific reports · 2017Article
- The Structure-function remodeling in rabbit hearts of myocardial infarction.Physiological reports · 2017Article
- A Novel Approach to Assess the In Situ Versus Ex Vivo Mechanical Behaviors of the Coronary Artery.Journal of biomechanical engineering · 2017Article
- Intraspecific scaling laws are preserved in ventricular hypertrophy but not in heart failure.American journal of physiology. Heart and circulatory physiology · 2016Article
- Microstructure-based biomechanics of coronary arteries in health and disease.Journal of biomechanics · 2016Review
- Growth, ageing and scaling laws of coronary arterial trees.Journal of the Royal Society, Interface · 2015Article
- Bio-Chemo-Mechanical Models of Vascular Mechanics.Annals of biomedical engineering · 2015Review
- Biaxial deformation of collagen and elastin fibers in coronary adventitia.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
- Microstructural constitutive model of active coronary media.Biomaterials · 2013Article
- Two-layer model of coronary artery vasoactivity.Journal of applied physiology (Bethesda, Md. : 1985) · 2013Article
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5 authors.
Funding
Abstract
The passive mechanical properties of blood vessel mainly stem from the interaction of collagen and elastin fibers, but vessel constriction is attributed to smooth muscle cell (SMC) contraction. Although the passive properties of coronary arteries have been well characterized, the active biaxial stress-strain relationship is not known. Here, we carry out biaxial (inflation and axial extension) mechanical tests in right coronary arteries that provide the active coronary stress-strain relationship in circumferential and axial directions. Based on the measurements, a biaxial active strain energy function is proposed to quantify the constitutive stress-strain relationship in the physiological range of loading. The strain energy is expressed as a Gauss error function in the physiological pressure range. In K(+)-induced vasoconstriction, the mean ± SE values of outer diameters at transmural pressure of 80 mmHg were 3.41 ± 0.17 and 3.28 ± 0.24 mm at axial stretch ratios of 1.3 and 1.5, respectively, which were significantly smaller than those in Ca(2+)-free-induced vasodilated state (i.e., 4.01 ± 0.16 and 3.75 ± 0.20 mm, respectively). The mean ± SE values of the inner and outer diameters in no-load state and the opening angles in zero-stress state were 1.69 ± 0.04 mm and 2.25 ± 0.08 mm and 126 ± 22°, respectively. The active stresses have a maximal value at the passive pressure of 80-100 mmHg and at the active pressure of 140-160 mmHg. Moreover, a mechanical analysis shows a significant reduction of mean stress and strain (averaged through the vessel wall). These findings have important implications for understanding SMC mechanics.
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