ArticleJournal of cachexia, sarcopenia and muscle2012
Molecular control of neuromuscular junction development.
Article in Journal of cachexia, sarcopenia and muscle, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed.
- Changes in the Structure of the Neuromuscular Junction and Muscle Fiber Types Following an Acute Injury Model Induced by Eccentric Contraction.Current issues in molecular biology · 2026Article
- Acetylcholine receptor-β inhibition by interleukin-6 in skeletal muscles contributes to modulating neuromuscular junction during aging.Molecular medicine (Cambridge, Mass.) · 2024Article
- Custom-made 3D-printed boot as a model of disuse-induced atrophy in murine skeletal muscle.PloS one · 2024Article
- Functional regeneration of the murine neuromuscular synapse relies on long-lasting morphological adaptations.BMC biology · 2022Article
- Control of CRK-RAC1 activity by the miR-1/206/133 miRNA family is essential for neuromuscular junction function.Nature communications · 2022Article
- Identification and molecular characterization of propionylcholinesterase, a novel pseudocholinesterase in rice.Plant signaling & behavior · 2021Article
- Creating stem cell-derived neuromuscular junctions in vitro.Muscle & nerve · 2021Review
- Ischemic stroke-induced polyaxonal innervation at the neuromuscular junction is attenuated by robot-assisted mechanical therapy.Experimental neurology · 2021Article
- The Neuromuscular Junction: Roles in Aging and Neuromuscular Disease.International journal of molecular sciences · 2021Review
- Association of regular aerobic exercises and neuromuscular junction variants with incidence of frailty: an analysis of the Chinese Longitudinal Health and Longevity Survey.Journal of cachexia, sarcopenia and muscle · 2021Article
- Juvenile Neuromuscular Systems Show Amplified Disturbance to Muscle Unloading.Frontiers in physiology · 2021Article
- A Novel Bioengineered Functional Motor Unit Platform to Study Neuromuscular Interaction.Journal of clinical medicine · 2020Article
- Pre-innervated tissue-engineered muscle promotes a pro-regenerative microenvironment following volumetric muscle loss.Communications biology · 2020Article
- Sex modifies the consequences of extended fructose consumption on liver health, motor function, and physiological damage in rats.American journal of physiology. Regulatory, integrative and comparative physiology · 2019Article
- Differentiation of Motor Neuron-Like Cells from Tonsil-Derived Mesenchymal Stem Cells and Their Possible Application to Neuromuscular Junction Formation.International journal of molecular sciences · 2019Article
- Stereotyped terminal axon branching of leg motor neurons mediated by IgSF proteins DIP-α and Dpr10.eLife · 2019Article
- Specific effects of neuregulin-1β on the communication between DRG neurons and skeletal muscle cells in vitro.Journal of muscle research and cell motility · 2018Article
- Muscle-restricted nuclear receptor interaction protein knockout causes motor neuron degeneration through down-regulation of myogenin at the neuromuscular junction.Journal of cachexia, sarcopenia and muscle · 2018Article
- Utrophin up-regulation by artificial transcription factors induces muscle rescue and impacts the neuromuscular junction in mdx mice.Biochimica et biophysica acta. Molecular basis of disease · 2018Article
- Bioreactor model of neuromuscular junction with electrical stimulation for pharmacological potency testing.Integrative biology : quantitative biosciences from nano to macro · 2017Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Skeletal muscle innervation is a multi-step process leading to the neuromuscular junction (NMJ) apparatus formation. The transmission of the signal from nerve to muscle occurs at the NMJ level. The molecular mechanism that orchestrates the organization and functioning of synapses is highly complex, and it has not been completely elucidated so far. Neuromuscular junctions are assembled on the muscle fibers at very precise locations called end plates (EP). Acetylcholine receptor (AChR) clusterization at the end plates is required for an accurate synaptic transmission. This review will focus on some mechanisms responsible for accomplishing the correct distribution of AChRs at the synapses. Recent evidences support the concept that a dual transcriptional control of AChR genes in subsynaptic and extrasynaptic nuclei is crucial for AChR clusterization. Moreover, new players have been discovered in the agrin-MuSK pathway, the master organizer of postsynaptical differentiation. Mutations in this pathway cause neuromuscular congenital disorders. Alterations of the postynaptic apparatus are also present in physiological conditions characterized by skeletal muscle wasting. Indeed, recent evidences demonstrate how NMJ misfunctioning has a crucial role at the onset of age-associated sarcopenia.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.