ArticleToxicology letters2012
Effects of acrylamide exposure on serum hormones, gene expression, cell proliferation, and histopathology in male reproductive tissues of Fischer 344 rats.
Article in Toxicology letters, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
21 citing papers in PubMed, 71 citations in OpenAlex.
- Morphological analysis and cytotoxicity of acrylamide on SPC212 human mesothelioma cells: Do low doses induce proliferation, while high doses cause toxicity?Journal of cellular and molecular medicine · 2024Article
- Impacts of Acrylamide on testis and spermatozoa.Molecular biology reports · 2024Review
- Protective roles of vitamin C and 5-aminosalicylic acid on reproduction in acrylamide intoxicated male mice.Saudi journal of biological sciences · 2023Article
- Association between acrylamide exposure and sex hormones among premenopausal and postmenopausal women: NHANES, 2013-2016.Journal of endocrinological investigation · 2023Article
- Reproductive Injury in Male Rats from Acrylamide Toxicity and Potential Protection by Earthworm Methanolic Extract.Animals : an open access journal from MDPI · 2022Article
- Testicular alterations in cryptorchid/orchiopexic rats chronically exposed to acrylamide or di-butyl-phthalate.Journal of toxicologic pathology · 2022Article
- Acrylamide in Baby Foods: A Probabilistic Exposure Assessment.Foods (Basel, Switzerland) · 2021Article
- Eruca sativa seed extract modulates oxidative stress and apoptosis and up-regulates the expression of Bcl-2 and Bax genes in acrylamide-induced testicular dysfunction in rats.Environmental science and pollution research international · 2021Article
- The effect of acrylamide on sperm oxidative stress, total antioxidant levels, tyrosine phosphorylation, and carboxymethyl-lysine expression: A laboratory study.International journal of reproductive biomedicine · 2021Article
- Interaction between dietary acrylamide intake and genetic variants for estrogen receptor-positive breast cancer risk.European journal of nutrition · 2019Article
- L-Cysteine Partially Protects Against Acrylamide-Induced Testicular Toxicity.Balkan medical journal · 2018Article
- Low dose assessment of the carcinogenicity of furan in male F344/N Nctr rats in a 2-year gavage study.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2017Article
- The influence of single nucleotide polymorphisms on the association between dietary acrylamide intake and endometrial cancer risk.Scientific reports · 2016Article
- Lack of adverse health effects following 30-weeks of dietary exposure to acrylamide at low doses in male F344 rats.Toxicology reports · 2016Article
- Transcriptomics analysis and hormonal changes of male and female neonatal rats treated chronically with a low dose of acrylamide in their drinking water.Toxicology reports · 2016Article
- Carcinogenicity of glycidamide in B6C3F1 mice and F344/N rats from a two-year drinking water exposure.Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2015Article
- Acrylamide toxic effects on mouse oocyte quality and fertility in vivo.Scientific reports · 2015Article
- Effects of lipoic Acid on acrylamide induced testicular damage.Materia socio-medica · 2014Article
- SOT Symposium Highlight: Translatable Indicators of Testicular Toxicity: Inhibin B, MicroRNAs, and Sperm Signatures.Toxicological sciences : an official journal of the Society of Toxicology · 2013Article
- Among 10 sociodemographic and lifestyle variables, smoking is strongly associated with biomarkers of acrylamide exposure in a representative sample of the U.S. Population.The Journal of nutrition · 2013Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
Acrylamide (AA) is a reactive monomer used in many technological applications, but it is the incidental formation during cooking of common starchy foods that leads to pervasive human exposure, typically in the range of 1 μg/kg body weight (bw)/day (d). AA is carcinogenic in multiple organs from both sexes of several rodent models and a consistent body of evidence points to a genotoxic mechanism based on metabolism to a DNA-reactive epoxide, glycidamide (GA). In F344 rats, tumorigenesis occurs in several hormonally regulated tissues (thyroid, mammary gland, and peri-testicular mesothelium), which has prompted speculation about endocrine dysregulation as a possible mechanism. The present study evaluated the effects of a 14 d exposure to AA administered through the drinking water on reproductive tissues and the hypothalamic-pituitary-testes (HPG) axis in male F344 rats. The doses selected encompass a range from approximately 2.5 mg/kg bw/d, which is carcinogenic after lifetime exposure, to 50 mg/kg bw/d, a maximally tolerable dose that causes hind limb paralysis. AA caused significant changes in serum hormones, histopathology, testicular gene expression, and cell proliferation, especially at the highest dose. Despite strong evidence for activation of the HPG axis subsequent to decreases in testosterone levels, and histopathological changes associated with significant effects on Leydig and germ cells, with concomitant mRNA expression changes, the precise mechanism(s) for AA-induced testicular toxicity remains unclear; however, the absence of evidence for increased proliferation of the peri-testicular mesothelium (Ki-67 immunoreactivity) does not support hormonal dysregulation as a contributing factor to the predisposition of this tissue to the carcinogenic effects of AA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.