ArticleScience (New York, N.Y.)2012
Control of sleep by cyclin A and its regulator.
Article in Science (New York, N.Y.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
45 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
- Parkinson's Disease is Associated with Dysregulations of a Dopamine-Modulated Gene Network Relevant to Sleep and Affective Neurobehaviors in the Striatum.Scientific reports · 2019Pooled it
- Cell-specific variant-to-gene mapping identifies conserved neural and glial regulators of sleep.bioRxiv : the preprint server for biology · 2026Article
- Behavioral adaptation to warm conditions via Lim1-mediated acceleration of neuronal clocks.Nature neuroscience · 2026Article
- Sleep regulation inFrontiers in neuroscience · 2026Review
- Clinical and genetic characterization of a progressive RBL2-associated neurodevelopmental disorder.Brain : a journal of neurology · 2025Article
- FlyVISTA, an integrated machine learning platform for deep phenotyping of sleep inScience advances · 2025Article
- FlyVISTA, an Integrated Machine Learning Platform for Deep Phenotyping of Sleep inbioRxiv : the preprint server for biology · 2024Article
- Behavioral screening of sleep-promoting effects of human intestinal and food-associated bacteria on Drosophila melanogaster.Genes to cells : devoted to molecular & cellular mechanisms · 2023Article
- Variant-to-gene mapping followed by cross-species genetic screening identifies GPI-anchor biosynthesis as a regulator of sleep.Science advances · 2023Article
- Article
- The 2020 Pittendrigh/Aschoff Lecture: My Circadian Journey.Journal of biological rhythms · 2021Article
- Molecular mechanisms and physiological importance of circadian rhythms.Nature reviews. Molecular cell biology · 2020Review
- Forward genetic approach for behavioral neuroscience using animal models.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2020Article
- Pumilio Regulates Sleep Homeostasis in Response to Chronic Sleep Deprivation inFrontiers in neuroscience · 2020Article
- Quantitative imaging of sleep behavior in Caenorhabditis elegans and larval Drosophila melanogaster.Nature protocols · 2019Article
- Article
- Genetic sleep deprivation: using sleep mutants to study sleep functions.EMBO reports · 2019Review
- A sleep-inducing gene,Science (New York, N.Y.) · 2019Article
- Control of Sleep Onset by Shal/KThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- The Neurobiological Basis of Sleep and Sleep Disorders.Physiology (Bethesda, Md.) · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
How and why the brain reversibly switches from a waking to a sleep state remain among the most intriguing questions in biology. We show that cyclin A (CycA) and regulator of cyclin A1, essential cell cycle factors, function in postmitotic neurons to promote sleep in Drosophila melanogaster. Reducing the abundance of CycA in neurons delayed the wake-sleep transition, caused multiple arousals from sleep, and reduced the homeostatic response to sleep deprivation. CycA is expressed in ~40 to 50 neurons in the adult brain, most of which are intermingled with circadian clock neurons, suggesting functional interactions among neurons controlling sleep and circadian behavior.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.