ReviewNeuroscience bulletin2012
Peripheral mechanisms of itch.
Review in Neuroscience bulletin, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 60 citations in OpenAlex.
- Effect of Intradermal Morphine on Histaminergic and Non-Histaminergic Itch: A Randomised, Single-Blinded, Human Study.Experimental dermatology · 2025Trial
- Recent Advances in Unraveling the Mechanisms of Pain and Itch: The Third Special Issue.Neuroscience bulletin · 2025Article
- The Role of Peripheral N-Methyl-D-Asparate (NMDA) Receptors in Itch and Pain: A Narrative Review.European journal of pain (London, England) · 2025Review
- Leveraging deep single-soma RNA sequencing to explore the neural basis of human somatosensation.Nature neuroscience · 2024Article
- Atopic dermatitis in early life and pain at 10 years of age: An exploratory study.European journal of pediatrics · 2024Article
- The lateral habenula nucleus regulates pruritic sensation and emotion.Molecular brain · 2023Article
- Druggable Targets and Compounds with Both Antinociceptive and Antipruritic Effects.Pharmaceuticals (Basel, Switzerland) · 2022Review
- Characteristics, mechanism, and management of pain in atopic dermatitis: A literature review.Clinical and translational allergy · 2021Review
- Oncostatin M can sensitize sensory neurons in inflammatory pruritus.Science translational medicine · 2021Article
- Review
- Induced Transient Immune Tolerance in Ticks and Vertebrate Host: A Keystone of Tick-Borne Diseases?Frontiers in immunology · 2021Review
- Riboflavin Inhibits Histamine-Dependent Itch by Modulating Transient Receptor Potential Vanilloid 1 (TRPV1).Frontiers in molecular neuroscience · 2021Article
- Cholestasis-Associated Pruritus and Its Pruritogens.Frontiers in medicine · 2021Review
- Inhibition of natriuretic peptide receptor 1 reduces itch in mice.Science translational medicine · 2019Article
- MRGPRX4 is a G protein-coupled receptor activated by bile acids that may contribute to cholestatic pruritus.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Cooling Relief of Acute and Chronic Itch Requires TRPM8 Channels and Neurons.The Journal of investigative dermatology · 2018Article
- Recent Progress in Understanding the Mechanisms of Pain and Itch: the Second Special Issue.Neuroscience bulletin · 2018Article
- TNF-α/TNFR1 Signaling is Required for the Full Expression of Acute and Chronic Itch in Mice via Peripheral and Central Mechanisms.Neuroscience bulletin · 2018Article
- Antioxidants Attenuate Acute and Chronic Itch: Peripheral and Central Mechanisms of Oxidative Stress in Pruritus.Neuroscience bulletin · 2017Article
- Mechanisms of pruritogen-induced activation of itch nerves in isolated mouse skin.The Journal of physiology · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Detection of environmental stimuli that provoke an aversive response has been shown to involve many receptors in the periphery. Probably the least-studied of these stimuli are those that induce the perception of itch (pruritus), an often-experienced unpleasant stimulus. This review covers the ligands and their receptors which are known to cause primary sensory neuron activation and initiate itch sensation. Also covered are several itch-inducing substances which may act indirectly by activating other cell types in the periphery which then signal to primary neurons. Finally, progress in identifying candidate neurotransmitters that sensory neurons use to propagate the itch signal is discussed.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.