SynthesisCurrent diabetes reports2012
Glycemic control and cardiovascular disease: what's a doctor to do?
Synthesis in Current diabetes reports, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04444570 (Continuous Glycemia Monitoring in Perioperative Period in Patients Undergoing Total Knee or Hip Arthroplasty), which is not on this map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Continuous Glycemia Monitoring in Perioperative Period in Patients Undergoing Total Knee or Hip Arthroplasty: a Protocol of Observational Study
Who cites it
16 citing papers in PubMed, 29 citations in OpenAlex.
- Beneficial Effects of a Freeze-Dried Kale Bar on Type 2 Diabetes Patients: A Randomized, Double-Blinded, Placebo-Controlled Clinical Trial.Nutrients · 2024Trial
- Trial
- Effectiveness of Pharmacist-Led Training Regarding Medication for Type 2 Diabetes, Based on Patient and Physician Medication-Related Issues Identified in China.Diabetes, metabolic syndrome and obesity : targets and therapy · 2025Article
- Awareness of cardiovascular risk among persons with type 2 diabetes: a qualitative study.International journal of qualitative studies on health and well-being · 2024Article
- Evaluation of cardiothoracic ratio as a potential predictor of cardiovascular abnormalities in individuals with type II diabetes mellitus: a case-control study.Journal of medicine and life · 2024Article
- Mitochondrial related variants associated with cardiovascular traits.Frontiers in physiology · 2024Article
- Observational
- Hypermethylation Effects of Yiqihuoxue Decoction in Diabetic Atherosclerosis Using Genome-Wide DNA Methylation Analyses.Journal of inflammation research · 2022Article
- Correlation between hemoglobin A1c and serum lipid profile in Afghani patients with type 2 diabetes: hemoglobin A1c prognosticates dyslipidemia.Therapeutic advances in endocrinology and metabolism · 2017Article
- Levels of Apolipoprotein A1, B100 and Lipoprotein (a) in Controlled and Uncontrolled Diabetic Patients and in Non-Diabetic Healthy People.Journal of clinical and diagnostic research : JCDR · 2017Article
- [Metabolic syndrome increases Framingham risk score of patients with type 2 diabetes mellitus].Zhejiang da xue xue bao. Yi xue ban = Journal of Zhejiang University. Medical sciences · 2016Article
- Initial therapy, persistence and regimen change in a cohort of newly treated type 2 diabetes patients.British journal of clinical pharmacology · 2015 · on this mapObservational
- A review of cardiovascular outcomes in the treatment of people with type 2 diabetes.Diabetes therapy : research, treatment and education of diabetes and related disorders · 2014Article
- Plasma triglycerides predict ten-years all-cause mortality in outpatients with type 2 diabetes mellitus: a longitudinal observational study.Cardiovascular diabetology · 2014Observational
- Clinical significance of glycated hemoglobin in the acute phase of ST elevation myocardial infarction.World journal of cardiology · 2014Review
- Trajectories in glycemic control over time are associated with cognitive performance in elderly subjects with type 2 diabetes.PloS one · 2014Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Cardiovascular disease (CVD) remains the leading cause of morbidity and mortality in individuals with diabetes mellitus. Moreover, rates of CVD mortality are two to four times higher in diabetes than in those without diabetes. It was conventional thinking that achieving near-normoglycemia would help reduce CVD risk and overall mortality in type 2 diabetes mellitus. Several recent large trials attempted to answer this question using a randomized control trial design with a conventional therapy and an intensive control arm. Surprisingly, these trials did not demonstrate neither mortality nor a CVD advantage with intensive glycemic control. Moreover, some studies (e.g., the ACCORD [Action to Control Cardiovascular Risk in Diabetes] study) showed increased mortality in the intensive control arm. In this review, our goal is to summarize the findings of the major trials in this field and to explore the potential reasons for why these trials had largely negative results. We conclude with some lessons that may be applied to the clinical management of patients with diabetes.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.