ArticleISRN endocrinology2012
Recent advances in obesity: genetics and beyond.
Article in ISRN endocrinology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 103 citations in OpenAlex.
- A Genomewide Integrative Analysis of GWAS and eQTLs Data Identifies Multiple Genes and Gene Sets Associated with Obesity.BioMed research international · 2018Pooled it
- A meta-analysis of reference values of leptin concentration in healthy postmenopausal women.PloS one · 2013Pooled it
- Nutrigenomics of Obesity: Integrating Genomics, Epigenetics, and Diet-Microbiome Interactions for Precision Nutrition.Life (Basel, Switzerland) · 2025Review
- Critical Correlation Between Obesity and Cardiovascular Diseases and Recent Advancements in Obesity.Cureus · 2024Review
- The Relationship Between Paternal Preconception Obesity and Health Behaviors and Childhood Obesity: Protocol for a Systematic Review.JMIR research protocols · 2021Article
- Metabolic and Molecular Subacute Effects of a Single Moderate-Intensity Exercise Bout, Performed in the Fasted State, in Obese Male Rats.International journal of environmental research and public health · 2021Article
- Effects of Tyrosine and Tryptophan Supplements on the Vital Indicators in Mice Differently Prone to Diet-Induced Obesity.International journal of molecular sciences · 2021Article
- High-fat diet increases the level of circulating Monocyte Chemoattractant Protein-1 in Wistar rats, independent of obesity.Annals of medicine and surgery (2012) · 2021Article
- Relationships of apelin concentration and APLN T-1860C polymorphism with obesity in Thai children.BMC pediatrics · 2020Article
- Exploring the Impact of Obesity on Skeletal Muscle Function in Older Age.Frontiers in nutrition · 2020Review
- Changes in Body Composition andDiabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Intracutaneous Delivery of Gelatins Reduces Fat Accumulation in Subcutaneous Adipose Tissue.Toxicological research · 2019Article
- Article
- Chemical and non-chemical stressors affecting childhood obesity: a systematic scoping review.Journal of exposure science & environmental epidemiology · 2018Article
- Role of MicroRNA Regulation in Obesity-Associated Breast Cancer: Nutritional Perspectives.Advances in nutrition (Bethesda, Md.) · 2017Review
- The genetic epidemiology of substance use disorder: A review.Drug and alcohol dependence · 2017Review
- Effect of six type II diabetes susceptibility loci and an FTO variant on obesity in Pakistani subjects.European journal of human genetics : EJHG · 2016Observational
- Nonlinear transcriptomic response to dietary fat intake in the small intestine of C57BL/6J mice.BMC genomics · 2016Article
- Allelic variants of the Melanocortin 4 receptor (MC4R) gene in a South African study group.Molecular genetics & genomic medicine · 2016Article
- Oral supplementations with L-glutamine or L-alanyl-L-glutamine do not change metabolic alterations induced by long-term high-fat diet in the B6.129F2/J mouse model of insulin resistance.Molecular and cellular biochemistry · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevalence of obesity, which is a heritable trait that arises from the interactions of multiple genes and lifestyle factors, continues to increase worldwide, causing serious health problems and imposing a substantial economic burden on societies. For the past several years, various genetic epidemiological approaches have been utilized to identify genetic loci for obesity. Recent evidence suggests that development of obesity involves hormones and neurotransmitters (such as leptin, cocaine- and amphetamine-regulated transcript (CART), and ghrelin) that regulate appetite and energy expenditure. These hormones act on specific centers in the brain that regulate the sensations of satiety. Mutations in these hormones or their receptors can lead to obesity. Aberrant circadian rhythms and biochemical pathways in peripheral organs or tissues have also been implicated in the pathology of obesity. More interestingly, increasing evidence indicates a potential relation between obesity and central nervous system disorders (such as cognitive deficits). This paper discusses recent advances in the field of genetics of obesity with an emphasis on several established loci that influence obesity. These recently identified loci may hold the promise to substantially improve our insights into the pathophysiology of obesity and open up new therapeutic strategies to combat growing obesity epidemic facing the human population today.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.