ArticleDatabase : the journal of biological databases and curation2012
MSV3d: database of human MisSense Variants mapped to 3D protein structure.
Article in Database : the journal of biological databases and curation, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
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- PSnpBind: a database of mutated binding site protein-ligand complexes constructed using a multithreaded virtual screening workflow.Journal of cheminformatics · 2022Article
- ADDRESS: A Database of Disease-associated Human Variants Incorporating Protein Structure and Folding Stabilities.Journal of molecular biology · 2021Article
- Next-Generation Sequencing and Mutational Analysis: Implications for Genes Encoding LINC Complex Proteins.Methods in molecular biology (Clifton, N.J.) · 2018Article
- Structural modeling and in silico analysis of non-synonymous single nucleotide polymorphisms of human 3β-hydroxysteroid dehydrogenase type 2.Meta gene · 2015Article
- Phenotypic and molecular analyses of primary lateral sclerosis.Neurology. Genetics · 2015Article
- AMASS: a database for investigating protein structures.Bioinformatics (Oxford, England) · 2014Article
- A comprehensive study of small non-frameshift insertions/deletions in proteins and prediction of their phenotypic effects by a machine learning method (KD4i).BMC bioinformatics · 2014Article
- SDS, a structural disruption score for assessment of missense variant deleteriousness.Frontiers in genetics · 2014Article
- An association-adjusted consensus deleterious scheme to classify homozygous Mis-sense mutations for personal genome interpretation.BioData mining · 2013Article
- Knowledge discovery in variant databases using inductive logic programming.Bioinformatics and biology insights · 2013Article
- KD4v: Comprehensible Knowledge Discovery System for Missense Variant.Nucleic acids research · 2012Article
- Identification of functional SNPs in BARD1 gene and in silico analysis of damaging SNPs: based on data procured from dbSNP database.PloS one · 2012Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The elucidation of the complex relationships linking genotypic and phenotypic variations to protein structure is a major challenge in the post-genomic era. We present MSV3d (Database of human MisSense Variants mapped to 3D protein structure), a new database that contains detailed annotation of missense variants of all human proteins (20 199 proteins). The multi-level characterization includes details of the physico-chemical changes induced by amino acid modification, as well as information related to the conservation of the mutated residue and its position relative to functional features in the available or predicted 3D model. Major releases of the database are automatically generated and updated regularly in line with the dbSNP (database of Single Nucleotide Polymorphism) and SwissVar releases, by exploiting the extensive Décrypthon computational grid resources. The database (http://decrypthon.igbmc.fr/msv3d) is easily accessible through a simple web interface coupled to a powerful query engine and a standard web service. The content is completely or partially downloadable in XML or flat file formats. Database URL: http://decrypthon.igbmc.fr/msv3d.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.