Evidence map›Paper›PMID 22505499›Full record

Trial reportJournal of perinatal medicine2012

Perinatal impact of the use of metformin and glyburide for the treatment of gestational diabetes mellitus.

Jean Carl Silva, Débora Raquel Rigon Narciso Fachin, Morgana Leonora Coral, Anna Maria Bertini

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Journal of perinatal medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 32 papers, 8 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 8 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01998113 completedstarted 2013, after this paper: background citation

Glyburide and Metformin for the Treatment of Gestational Diabetes Mellitus. A Systematic Review and Meta-analysis of Randomized Controlled Trials Comparing These Drugs Either vs Insulin or vs Each Other.

Ran2013Enrolled2,509Registered outcomes30Posted comparisons0ConditionsGestational Diabetes MellitusArmsGlyburide vs Insulin trials, Metformin vs Glyburide trials, Metformin vs Insulin trials
PMID 20739011PMID 19104375PMID 18463376PMID 11036118PMID 23724063other papers from this trial
Open the trial in the graph
NCT06589141 nanot yet recruitingstarted 2025, after this paper: background citation

Comparison Between Metformin and Glyburide in the Management of Gestational Diabetes: a Randomized Controlled Trial (GDM-MERGE Trial)

Ran2025Enrolled180Registered outcomes4Posted comparisons0ConditionsGestational Diabetes Mellitus in PregnancyArmsGlyBURIDE 2.5 MG Oral Tablet, MetFORMIN 500 Mg Oral Tablet
PMID 31869430PMID 35195193PMID 35613728other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 8 syntheses or guidelines pooled it.

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  16. Treatment of Gestational Diabetes Mellitus and Offspring Early Childhood Growth.The Journal of clinical endocrinology and metabolism · 2021
    Article
  17. Factors Associated with the Need for Insulin as a Complementary Treatment to Metformin in Gestational Diabetes Mellitus.Revista brasileira de ginecologia e obstetricia : revista da Federacao Brasileira das Sociedades de Ginecologia e Obstetricia · 2019
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jean Carl SilvaDepartment of Obstetrics, Universidade da Região de Joinville (UNIVILLE), Joinville, Brazil.
Débora Raquel Rigon Narciso Fachin
Morgana Leonora Coral
Anna Maria Bertini

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate the perinatal impact of metformin and glyburide in the treatment of gestational diabetes mellitus (GDM).

methodsA randomized clinical trial conducted from July 2008 until September 2010 studied 200 pregnant women with GDM who required adjunctive therapy to diet and physical activity. Patients were randomized to use metformin (n=104) or glyburide (n=96). The drugs were replaced by insulin when they reached the maximum dose without glycemic control. Assessed outcomes: weight and neonatal blood glucose.

resultsNo difference was found (P>0.05) between the groups regarding maternal age, gestational age at inclusion, body mass index, glucose levels in oral glucose tolerance test (OGTT) 75 g and glycemic control. Difference was found in the number of previous pregnancies (2.84 vs. 2.47, P=0.04) and weight gain during pregnancy (7.78 vs. 9.84, P=0.04) in the metformin group and glyburide respectively. The perinatal results showed no difference (P>0.05) in the percentage of cesarean deliveries, gestational age at delivery, number of newborns large for gestational age (LGA), neonatal hypoglycemia, admission to intensive care unit and perinatal death. We found differences in weight (3193 g vs. 3387 g, P=0.01) and ponderal index (2.87 vs. 2.96, P=0.05) of newborns, and in neonatal blood glucose levels at the 1st (59.78 vs. 54.08, P=0.01) and 3rd h (61.53 vs. 55.89, P=0.01) after birth between the metformin and glyburide groups respectively.

conclusionsWeight and ponderal index were lower in the newborns of the metformin group; glucose levels (1st and 3rd h after birth) were lower in the glyburide group.

Indexed as

AdultBirth WeightBlood GlucoseDiabetes, GestationalFemaleGlucose Tolerance TestGlyburideHumansHypoglycemic AgentsInfant, NewbornMaleMetforminPregnancyPregnancy OutcomeWeight GainBlood GlucoseGlyburideHypoglycemic AgentsMetformin

Identifiers

PMID22505499

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.