ReviewAmerican journal of cardiovascular drugs : drugs, devices, and other interventions2012
Role of antihypertensive drugs in arterial 'de-stiffening' and central pulsatile hemodynamics.
Review in American journal of cardiovascular drugs : drugs, devices, and other interventions, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02887677 (A Study of the Effects of Dapagliflozin on Ambulatory Aortic Pressure, Arterial Stiffness and Urine Albumin Excretion in Patients With Type 2 Diabetes), which is not on this map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Study of the Effects of Dapagliflozin on Ambulatory Aortic Pressure, Arterial Stiffness and Urine Albumin Excretion in Patients With Type 2 Diabetes
Who cites it
16 citing papers in PubMed.
- Increased plasma ceramide levels are associated with arterial stiffness and vascular ageing: a cross-sectional study.Lipids in health and disease · 2025Article
- Arterial stiffness and vascular aging: mechanisms, prevention, and therapy.Signal transduction and targeted therapy · 2025Review
- Effect of low-dose terazosin on arterial stiffness improvement: A pilot study.Journal of cellular and molecular medicine · 2024Article
- Dissociation of pulse wave velocity and aortic wall stiffness in diabetic db/db mice: The influence of blood pressure.Frontiers in physiology · 2023Article
- Association of impaired arterial wall properties with the presence of coronary artery disease in patients with abdominal aortic aneurysms.Journal of clinical hypertension (Greenwich, Conn.) · 2020Article
- Arterial stiffness correlates with progressive nailfold capillary microscopic changes in systemic sclerosis: results from a cross-sectional study.Arthritis research & therapy · 2019Article
- Pulse wave velocity as a measure of arterial stiffness in patients with familial hypercholesterolemia: a systematic review and meta-analysis.Archives of medical science : AMS · 2019Review
- Determinants of Vascular Age: An Epidemiological Perspective.Clinical chemistry · 2019Review
- Arterial stiffness in elderly patients with normotension and hypertension in Brazil.Journal of clinical hypertension (Greenwich, Conn.) · 2018Article
- Interactions between the Cyclooxygenase Metabolic Pathway and the Renin-Angiotensin-Aldosterone Systems: Their Effect on Cardiovascular Risk, from Theory to the Clinical Practice.BioMed research international · 2018Review
- Association of Central Arterial Stiffness and Pressure Pulsatility with Mild Cognitive Impairment and Dementia: The Atherosclerosis Risk in Communities Study-Neurocognitive Study (ARIC-NCS).Journal of Alzheimer's disease : JAD · 2017Article
- Fitness: The "Secret" of Vascular Youth.Journal of clinical hypertension (Greenwich, Conn.) · 2016Article
- Effect of angiotensin II-induced arterial hypertension on the voltage-dependent contractions of mouse arteries.Pflugers Archiv : European journal of physiology · 2016Article
- Is There an Association Between Carotid-Femoral Pulse Wave Velocity and Coronary Heart Disease in Patients with Coronary Artery Disease: A Pilot Study.The open cardiovascular medicine journal · 2016Article
- Effects of different types of antihypertensive agents on arterial stiffness: a systematic review and meta-analysis of randomized controlled trials.Journal of thoracic disease · 2015Article
- Arterial stiffness and cardiovascular therapy.BioMed research international · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Arterial stiffness is an independent predictor of cardiovascular (CV) morbidity and mortality in patients with hypertension, as well as a potential therapeutic target. There is increasing awareness that the pulsatile hemodynamics (central blood pressure [CBP], pulse pressure [PP], wave reflections [augmentation index or AIx] and pulse wave velocity [PWV]) may provide better insight into the pathophysiology of CV disorders and target organ damage related to hypertension. Different antihypertensive drugs produce diverse effects on arterial stiffness variables, despite similar effects on peripheral (brachial) blood pressure. Identifying the pharmacologic interventions that can improve arterial stiffness ('de-stiffening' treatment) is a promising field of research.
Indexed as
Identifiers
22540323What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.