ArticleFrontiers in genetics2012
P-selectin Expression Tracks Cerebral Atrophy in Mexican-Americans.
Article in Frontiers in genetics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 13 citations in OpenAlex.
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- Association of Blood Pressure, White Matter Lesions, and Regional Cerebral Blood Flow.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- Genomic kinship construction to enhance genetic analyses in the human connectome project data.Human brain mapping · 2019Article
- Lipid Metabolism, Abdominal Adiposity, and Cerebral Health in the Amish.Obesity (Silver Spring, Md.) · 2017Article
- Combining diffusion tensor imaging and magnetic resonance spectroscopy to study reduced frontal white matter integrity in youths with family histories of substance use disorders.Human brain mapping · 2014Article
- Accelerated white matter aging in schizophrenia: role of white matter blood perfusion.Neurobiology of aging · 2014Article
- Multimodal white matter imaging to investigate reduced fractional anisotropy and its age-related decline in schizophrenia.Psychiatry research · 2014Article
- Lower neurocognitive function in U-2 pilots: Relationship to white matter hyperintensities.Neurology · 2014Article
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Authors and funding
19 authors at 4 institutions in 1 country.
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Abstract
background and purposeWe hypothesized that the P-selectin (SELP) gene, localized to a region on chromosome 1q24, pleiotropically contributes to increased blood pressure and cerebral atrophy. We tested this hypothesis by performing genetic correlation analyses for 13 mRNA gene expression measures from P-selectin and 11 other genes located in 1q24 region and three magnetic resonance imaging derived indices of cerebral integrity.
methodsThe subject pool consisted of 369 (219F; aged 28-85, average = 47.1 ± 12.7 years) normally aging, community-dwelling members of large extended Mexican-American families. Genetic correlation analysis decomposed phenotypic correlation coefficients into genetic and environmental components among 13 leukocyte-based mRNA gene expressions and three whole-brain and regional measurements of cerebral integrity: cortical gray matter thickness, fractional anisotropy of cerebral white matter, and the volume of hyperintensive WM lesions.
resultsFrom the 13 gene expressions, significant phenotypic correlations were only found for the P- and L-selectin expression levels. Increases in P-selectin expression levels tracked with decline in cerebral integrity while the opposite trend was observed for L-selectin expression. The correlations for the P-selectin expression were driven by shared genetic factors, while the correlations with L-selectin expression were due to shared environmental effects.
conclusionThis study demonstrated that P-selectin expression shared a significant variance with measurements of cerebral integrity and posits elevated P-selectin expression levels as a potential risk factor of hypertension-related cerebral atrophy.
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