ReviewInternational journal of stroke : official journal of the International Stroke Society2013
Single subcortical infarction associated with parental arterial disease: important yet neglected sub-type of atherothrombotic stroke.
Review in International journal of stroke : official journal of the International Stroke Society, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 40 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Trial of PCSK9 Inhibition in Patients with Acute Stroke and Symptomatic Intracranial Atherosclerosis - a Prospective, Randomized, Open-label, Blinded End-point Study with High-resolution MR Vessel Wall Imaging
Early Intensive Medical Therapy for the Prevention of Early Neurological Deterioration in Branch Atheromatous Disease
Study on Tirofiban With Aspirin in the Treatment of Acute Penetrating Artery Territory Infarction (STRATEGY)
Who cites it
40 citing papers in PubMed, 75 citations in OpenAlex.
- Early vs Delayed Antihypertensive Treatment in Acute Single Subcortical Infarction: A Secondary Analysis of the CATIS-2 Randomized Clinical Trial.JAMA network open · 2024Trial
- Genotype-Guided Dual Antiplatelet Therapy in Minor Stroke or Transient Ischemic Attack With a Single Small Subcortical Infarction.Neurology · 2023Trial
- Different Characteristics of Incidental Diffusion-Weighted Imaging-Positive Lesions and Recent Small Subcortical Infarct in Patients With Cerebral Small Vessel Disease.Journal of the American Heart Association · 2026Article
- Parent Artery Disease-Related Stroke: What Is the Impact on Endovascular Treatment? A Narrative Review.Journal of clinical medicine · 2026Review
- Proximal Single Subcortical Infarction, Left Ventricular Fractional Shortening, and Risk Prediction Model Development for Neurological Deterioration in Patients With Anterior Circulation Single Subcortical Infarction.Journal of the American Heart Association · 2025Observational
- Early intensive therapy for preventing neurological deterioration in branch atheromatous disease.Therapeutic advances in neurological disorders · 2025Article
- Serum fibrinogen/albumin ratio and early neurological deterioration in patients with recent small subcortical infarction.Annals of medicine · 2024Article
- Small vessel disease burden and prognosis of recent subcortical ischaemic stroke differ by parent artery atherosclerosis.European journal of neurology · 2024Article
- Lesion Indexes Predict Early Neurologic Deterioration in Lenticulostriate Single Small Subcortical Infarction.AJNR. American journal of neuroradiology · 2024Article
- White matter hyperintensity, parent artery steno-occlusion, and neurological deterioration in anterior circulation single subcortical infarction patients.Brain and behavior · 2024Article
- Enlarged Perivascular Space in the Basal Ganglia is Associated with Cerebral Venous Reflux in Patients with Recent Small Subcortical Infarction.Current neurovascular research · 2024Article
- Preliminary results on temporal evolution and clinical implications of atherosclerotic plaque in branch atheromatous disease after statin treatment.Therapeutic advances in neurological disorders · 2024Article
- Morphological predictors of neurological deterioration in patients with acute isolated pontine infarct.Acta neurologica Belgica · 2023Article
- Evaluation of clinical relevance and underlying pathology for hemodynamic compromise in acute small subcortical infarction using MRI-based neuroimaging markers.Biomedical journal · 2023Article
- Infarct growth velocity predicts early neurological outcomes in single subcortical infarction.Scientific reports · 2023Article
- Clinical factors associated with functional outcomes in patients with single subcortical infarction with neurological deterioration.Frontiers in neurology · 2023Article
- The impact of asymptomatic intracranial atherosclerotic stenosis on the clinical outcomes of patients with single subcortical infarction.Frontiers in medicine · 2023Article
- Perfusion Defects and Collateral Flow Patterns in Acute Small Subcortical Infarction: a 4D Dynamic MRI Study.Translational stroke research · 2022Article
- Small Vessel Disease, a Marker of Brain Health: What the Radiologist Needs to Know.AJNR. American journal of neuroradiology · 2022Review
- Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTraditionally, single subcortical infarction has been considered to be caused by lipohyalinosis of small perforating arteries. However, atherosclerosis in the parental artery produces similar single subcortical infarction by blocking the orifice of branching arteries. The purpose of this paper is to review the evolving concepts, clinical characteristics, and classification issues of single subcortical infarction associated with parental artery disease. SUMMARY OF REVIEW: Single subcortical infarction associated with parental artery disease is an important cause of subcortical infarction, more so in the posterior than in anterior circulation stroke. It is one of the major causes of brainstem infarction. Single subcortical infarction associated with parental artery disease seems to be common in Asian population where intracranial atherosclerosis is prevalent. Although the clinical characteristics of single subcortical infarction associated with parental artery disease are similar to single subcortical infarction caused by small artery disease, single subcortical infarction associated with parental artery disease is more often associated with characteristics of atherosclerosis, and fluctuating and poorer outcomes. With advanced imaging techniques such as high-resolution cross-sectional magnetic resonance imaging, single subcortical infarction associated with parental artery disease emerges as an even more important stroke sub-type. Nevertheless, it has been neglected in previous stroke sub-type classifications, being erroneously classified as small artery disease or cryptogenic stroke. Prevention and treatment trials focusing on single subcortical infarction associated with parental artery disease are not available.
conclusionSingle subcortical infarction associated with parental artery disease is an important stroke sub-type, distinct from small artery disease, illustrating that greater efforts should be made in its accurate diagnosis. Studies are needed to investigate the prevalence of single subcortical infarction associated with parental artery disease in various parts of the world and to design a stroke classification system that includes single subcortical infarction associated with parental artery disease. Prevention and treatment trials should consider this important sub-group of stroke, so that tailored strategies can be applied in clinical practice.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.