ArticleMetabolic brain disease2012
Alzheimer's disease and type 2 diabetes: the association study of polymorphisms in tumor necrosis factor-alpha and apolipoprotein E genes.
Article in Metabolic brain disease, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 4 of them syntheses that pooled it.
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Who cites it
10 citing papers in PubMed, 4 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Association of apolipoprotein E polymorphisms (E2, E3, E4) with type 2 diabetes: a meta-analysis of case-control studies.The Pan African medical journal · 2026Pooled it
- The association of TNF-α -308G/A and -238G/A polymorphisms with type 2 diabetes mellitus: a meta-analysis.Bioscience reports · 2019Pooled it
- The TNF-alpha -308G/A polymorphism is associated with type 2 diabetes mellitus: an updated meta-analysis.Molecular biology reports · 2014Pooled it
- A meta-analysis of the association between TNF-α -308G>A polymorphism and type 2 diabetes mellitus in Han Chinese population.PloS one · 2013Pooled it
- Harnessing the benefits of physical exercise-induced melatonin: a potential promising approach to combat Alzheimer's disease by targeting beta-amyloid (Aβ).Hormones (Athens, Greece) · 2025Review
- The neuroprotective role of melatonin in neurological disorders.Journal of neuroscience research · 2018Review
- APOE Genotypes Associate With Cognitive Performance but Not Cerebral Structure: Diabetes Heart Study MIND.Diabetes care · 2016Article
- Genetic polymorphisms of cytokine genes in type 2 diabetes mellitus.World journal of diabetes · 2014Review
- Association of IL-6, TNF-α and IL-10 gene polymorphisms with type 2 diabetes mellitus.Molecular biology reports · 2013Article
- Melatonin in Alzheimer's disease.International journal of molecular sciences · 2013Review
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Type 2 diabetes (T2D) and Alzheimer's disease (AD) are two progressive disorders with high prevalence worldwide. Polymorphisms in tumor necrosis factor-alpha (TNF-α) and apolipoprotein E (ApoE) genes might be associated with both T2D and AD, representing possible genetic markers for the development of the AD in subjects with T2D. The aim was to determine ApoE and G-308A TNF-α gene polymorphisms in unrelated Croatian Caucasians: 207 patients with sporadic AD, 196 T2D patients and 456 healthy controls. Patients with AD had higher frequency of ApoE4 allele compared to T2D patients and controls. The significant association, observed between ApoE2 allele and T2D, disappeared after the data were adjusted for age and sex. The genotype or allele frequencies of G-308A TNF-α gene polymorphism were similar among the patients with AD, T2D and healthy controls. In conclusion, these results do not support the hypothesis that the A allele of G-308A TNF-α gene polymorphism is associated either with AD or T2D. Our data confirm the association between the ApoE4 allele and AD, and point out the E2 allele of ApoE gene as the possible risk factor for T2D.
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