ArticleThe review of diabetic studies : RDS2011
Normal fasting plasma glucose and risk of prediabetes and type 2 diabetes: the Isfahan Diabetes Prevention Study.
Article in The review of diabetic studies : RDS, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04511468 (A Combination of Zinc, Chromium, Vitamin C, and Copper Supplement for Prediabetes Progression), which is not on this map. Cited by 14 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Combination of Zinc, Chromium, Vitamin C, and Copper Supplement for Prediabetes Progression: Randomized Controlled-Trial in Jakarta
Who cites it
14 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Development of type 2 diabetes mellitus in people with intermediate hyperglycaemia.The Cochrane database of systematic reviews · 2018Pooled it
- Baseline Fasting Glucose Level, Age, Sex, and Body Mass Index and the Development of Diabetes in US Adults.JAMA network open · 2025Article
- Fasting Plasma Glucose Levels within the High Normal Range are Associated with a Significantly Increased Risk of Future Dysglycemia in Transfusion-Dependent β Thalassemia: A Decade-Long Multicenter Retrospective Analysis.Mediterranean journal of hematology and infectious diseases · 2025Article
- Conceptual Overview of Prevalence of Prediabetes.Current diabetes reviews · 2025Review
- Comparison of triglyceride/glucose index and related parameters with Indian Diabetes Risk Score assessment in non-diabetic individuals visiting primary healthcare centre-A community-based cross-sectional study.Journal of family medicine and primary care · 2024Article
- Finnish diabetes risk score outperformed triglyceride-glucose index in diabetes risk prediction.Journal of diabetes and metabolic disorders · 2023Article
- J-shape relationship between normal fasting plasma glucose and risk of type 2 diabetes in the general population: results from two cohort studies.Journal of translational medicine · 2023Article
- Association of cardiometabolic risk factors with insulin resistance in overweight and obese children.BMC endocrine disorders · 2022Article
- Triglyceride glucose index for the detection of the severity of coronary artery disease in different glucose metabolic states in patients with coronary heart disease: a RCSCD-TCM study in China.Cardiovascular diabetology · 2022Article
- A Prediction Model for Prediabetes Risk in Middle-Aged and Elderly Populations: A Prospective Cohort Study in China.International journal of endocrinology · 2021Article
- Correlates of fasting blood glucose among children living with hiv in a Nigerian tertiary hospital: a cross-sectional study.BMC pediatrics · 2020Article
- The product of fasting plasma glucose and triglycerides improves risk prediction of type 2 diabetes in middle-aged Koreans.BMC endocrine disorders · 2018Article
- Normal fasting plasma glucose predicts type 2 diabetes and cardiovascular disease in elderly population in Taiwan.QJM : monthly journal of the Association of Physicians · 2016Article
- Prevalence of high normal FBS and prediabetes among adolescents in Birjand, East of Iran, 2012.Journal of education and health promotion · 2015Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo determine the association of fasting plasma glucose (FPG) level within normal range and the risk of prediabetes and type 2 diabetes in an Iranian population.
methodsA total of 806 first-degree relatives (FDRs) of patients with type 2 diabetes who had FPG levels less than 5.6 mmol/l (100 mg/dl) in 2003 to 2005, and who did not have diabetes or impaired fasting glucose (IFG), were followed through 2010 for the occurrence of prediabetes or type 2 diabetes. At baseline and through follow-ups, participants underwent a standard 75 g 2-hour oral glucose tolerance test (OGTT).
resultsThe incidence of type 2 diabetes, impaired glucose tolerance (IGT), and IFG was 9.6 (95% confidence interval (CI): 6.8-12.4), 28.7 (23.8-33.6), and 33.0 (27.7-38.2) per 1,000 person-years based on 4,489 person-years of follow-up, respectively. FPG was associated with the incidence of diabetes, IGT, and IFG. The multivariate-adjusted hazard ratios (95% CI) for diabetes, IGT, and IFG were 1.36 (1.01-1.84), 1.45 (1.10-1.91) and 1.31 (1.00-1.71), for the highest quintile of FPG compared with the lowest quintile, respectively.
conclusionsAn increase in FPG in the normal range is associated with an increase in the incidence of IGT, IFG, and type 2 diabetes. These results prove FPG in the normal range to be useful in identifying apparently healthy FDRs of patients with type 2 diabetes at risk of developing prediabetes and diabetes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.