ArticleDiabetes care2012
Plasma fatty acid-binding protein 4, nonesterified fatty acids, and incident diabetes in older adults.
Article in Diabetes care, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed, 52 citations in OpenAlex.
- Integrated hepatic transcriptome and metabolome reveal the mechanisms of Jiangtang Tiaozhi formula on improving glycolipid metabolic disorder.World journal of diabetes · 2026Article
- Proteomic Signature of BMI and Risk of Type 2 Diabetes.Diabetes · 2025Article
- Sleep disordered breathing and circulating non-esterified fatty acids: the cardiovascular health study.Sleep advances : a journal of the Sleep Research Society · 2025Article
- Free fatty acids: independent predictors of long-term adverse cardiovascular outcomes in heart failure patients.Lipids in health and disease · 2024Article
- Higher circulating levels of non-esterified fatty acids are associated with faster kidney function decline in post-menopausal women with type 2 diabetes: a pilot prospective study.Acta diabetologica · 2024Article
- Association between Serum Free Fatty Acids and Clinical and Laboratory Parameters in Acute Heart Failure Patients.Biomedicines · 2023Article
- The determinants of fasting and post-load non-esterified fatty acids in older adults: The cardiovascular health study.Metabolism open · 2023Article
- Fasting and Post-Load Glucose and Non-Esterified Fatty Acids and Risk of Heart Failure and Its Subtypes in Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2023Article
- Circulating metabolic signatures of heart failure in precision cardiology.Precision clinical medicine · 2023Review
- Fasting and Postload Nonesterified Fatty Acids and Glucose Dysregulation in Older Adults.American journal of epidemiology · 2022Article
- Nonesterified Fatty Acids and Kidney Function Decline in Older Adults: Findings From the Cardiovascular Health Study.American journal of kidney diseases : the official journal of the National Kidney Foundation · 2021Article
- Serum fatty acid-binding protein 4 levels and responses of pancreatic islet β-cells and α-cells in patients with type 2 diabetes.Diabetology & metabolic syndrome · 2021Article
- Nonesterified Fatty Acids and Hospitalizations Among Older Adults: The Cardiovascular Health Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2021Article
- Sex Dimorphic Associations of Gestational Diabetes Mellitus With Cord Plasma Fatty Acid Binding Protein 4 and Estradiol.Frontiers in endocrinology · 2021Article
- Serum Free Fatty Acids Independently Predict Adverse Outcomes in Acute Heart Failure Patients.Frontiers in cardiovascular medicine · 2021Article
- The influence of equine body weight gain on inflammatory cytokine expressions of adipose tissue in response to endotoxin challenge.Acta veterinaria Scandinavica · 2020Article
- Fatty Acid Binding Protein-4 and Risk of Cardiovascular Disease: The Cardiovascular Health Study.Journal of the American Heart Association · 2020Observational
- Adipokine FABP4 integrates energy stores and counterregulatory metabolic responses.Journal of lipid research · 2019Review
- Using a Targeted Proteomics Chip to Explore Pathophysiological Pathways for Incident Diabetes- The Malmö Preventive Project.Scientific reports · 2019Article
- Plasma levels of free fatty acid differ in patients with left ventricular preserved, mid-range, and reduced ejection fraction.BMC cardiovascular disorders · 2018Observational
Corrections and comments
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Authors and funding
10 authors at 6 institutions in 1 country.
Funding
Abstract
objectiveTo examine the relation of fatty acid-binding protein (FABP)4 and nonesterified fatty acids (NEFAs) to diabetes in older adults. RESEARCH DESIGN AND
methodsWe ascertained incident diabetes among 3,740 Cardiovascular Health Study participants (1992-2007) based on the use of hypoglycemic medications, fasting glucose ≥ 126 mg/dL, or nonfasting glucose ≥ 200 mg/dL. FABP4 and NEFA were measured on specimens collected between 1992 and 1993.
resultsMean age of the 3,740 subjects studied was 74.8 years. For each SD increase in log FABP4, hazard ratios (HRs) for diabetes were 1.35 (95% CI 1.10-1.65) for women and 1.45 (1.13-1.85) for men controlling for age, race, education, physical activity, cystatin C, alcohol intake, smoking, self-reported health status, and estrogen use for women (P for sex-FABP4 interaction 0.10). BMI modified the FABP4-diabetes relation (P = 0.009 overall; 0.02 for women and 0.135 for men), in that statistically significant higher risk of diabetes was mainly seen in men with BMI <25 kg/m(2) (HR per SD: 1.78 [95% CI 1.13-2.81]). There was a modest and nonsignificant association of NEFA with diabetes (P(trend) = 0.21). However, when restricted to the first 5 years of follow-up, multivariable-adjusted HRs for diabetes were 1.0 (ref.), 1.68 (95% CI 1.12-2.53), and 1.63 (1.07-2.50) across consecutive tertiles of NEFA (P(trend) = 0.03).
conclusionsPlasma FABP4 was positively associated with incident diabetes in older adults, and such association was statistically significant in lean men only. A significant positive association between plasma NEFA and incident diabetes was observed during the first 5 years of follow-up.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.