Evidence map›Paper›PMID 22596255›Full record

SynthesisEndocrine reviews2012

The nonskeletal effects of vitamin D: an Endocrine Society scientific statement.

Clifford J Rosen, John S Adams, Daniel D Bikle, Dennis M Black, Marie B Demay, JoAnn E Manson, M Hassan Murad, Christopher S Kovacs

Open access · bronzeAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Endocrine reviews, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 297 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
297citing papers in PubMed, 13 pooled it
43.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

297 citing papers in PubMed, 13 syntheses or guidelines pooled it, 752 citations in OpenAlex.

  1. Pooled it
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  12. Guideline
  13. Pooled it
  14. Trial
  15. Trial
  16. Vitamins DFrontiers in immunology · 2022
    Trial
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  20. Trial

237 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 7 institutions in 2 countries.

Clifford J RosenTufts University School of Medicine, Boston, MA 02111, USA. crofen@gmail.com
John S Adams
Daniel D Bikle
Dennis M Black
Marie B Demay
JoAnn E Manson
M Hassan Murad
Christopher S Kovacs
University of California, San Francisco · USHarvard University · USMassachusetts General Hospital · USMayo Clinic · USMemorial University of Newfoundland · CATufts University · USUniversity of California, Los Angeles · US

Funding

UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
VITamin D and omegA-3 triaL (VITAL)U01CA138962 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI BURING, JULIE E., MANSON, JOANN ELISABETH · 2009 to 2014
$23.6M
UCLA CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR033176 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2011 to 2011
$15.5M
Interdisciplinary Study of Marrow Adiposity, Mineral Metabolism & Energy BalanceR24DK092759 · NIDDK · MAINEHEALTH · PI HOROWITZ, MARK C, MACDOUGALD, ORMOND A · 2011 to 2019
$13.0M
VITAMIN D RECEPTOR ABLATION: DIRECT AND INDIRECT CONSEQUENCESR01DK046974 · NIDDK · MASSACHUSETTS GENERAL HOSPITAL · PI DEMAY, MARIE · 1993 to 2015
$5.0M
Regenerative Musculoskeletal Medicine Training ProgramT32AR059033 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI John S Adams, Nicholas M. Bernthal · 2011 to 2026
$4.8M
Vitamin D Receptor Coactivators in KeratinocytesR01AR050023 · NIAMS · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI BIKLE, DANIEL DAVID · 2004 to 2014
$3.4M
Role of Vitamin D Prohormone 25-OHD in the Innate Immune Response to TuberculosisR01AI073539 · NIAID · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MODLIN, ROBERT L · 2008 to 2012
$2.0M
Orthopaedic Wear Debris, Vitamin D, and Innate ImmunityR21AR056885 · NIAMS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ADAMS, JOHN S · 2009 to 2010
$379k
Role of vitamin D and calcium signaling in wound healingI01BX001066 · VA · VETERANS AFFAIRS MED CTR SAN FRANCISCO · PI BIKLE, DANIEL DAVID · 2011 to 2014
–
BLRD VA I01 BX001066CIHR MOP-84253NCATS NIH HHS UL1 TR000124NCATS NIH HHS UL1TR000124NCI NIH HHS CA13896NCI NIH HHS U01 CA138962NCRR NIH HHS UL1 RR033176NCRR NIH HHS UL1RR033176NIAID NIH HHS R01 AI073539NIAID NIH HHS R01AI073539NIAMS NIH HHS R01 AR050023NIAMS NIH HHS R21 AR056885NIAMS NIH HHS R21AR056885NIAMS NIH HHS T32 AR059033NIAMS NIH HHS T32AR059033NIDDK NIH HHS DK092759NIDDK NIH HHS DK46974NIDDK NIH HHS R01 DK046974NIDDK NIH HHS R24 DK092759
6 · The paper itself

Abstract

Significant controversy has emerged over the last decade concerning the effects of vitamin D on skeletal and nonskeletal tissues. The demonstration that the vitamin D receptor is expressed in virtually all cells of the body and the growing body of observational data supporting a relationship of serum 25-hydroxyvitamin D to chronic metabolic, cardiovascular, and neoplastic diseases have led to widespread utilization of vitamin D supplementation for the prevention and treatment of numerous disorders. In this paper, we review both the basic and clinical aspects of vitamin D in relation to nonskeletal organ systems. We begin by focusing on the molecular aspects of vitamin D, primarily by examining the structure and function of the vitamin D receptor. This is followed by a systematic review according to tissue type of the inherent biological plausibility, the strength of the observational data, and the levels of evidence that support or refute an association between vitamin D levels or supplementation and maternal/child health as well as various disease states. Although observational studies support a strong case for an association between vitamin D and musculoskeletal, cardiovascular, neoplastic, and metabolic disorders, there remains a paucity of large-scale and long-term randomized clinical trials. Thus, at this time, more studies are needed to definitively conclude that vitamin D can offer preventive and therapeutic benefits across a wide range of physiological states and chronic nonskeletal disorders.

Indexed as

Accidental FallsAnimalsCardiovascular DiseasesDiabetes Mellitus, Type 2Dietary SupplementsFemaleFetal DevelopmentHumansMaleMiceMusculoskeletal DiseasesNeoplasmsObesityPregnancyQuality of LifeRandomized Controlled Trials as TopicReceptors, CalcitriolVitamin D

Identifiers

PMID22596255
PMCPMC3365859
OpenAlexW1976472175

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.