Evidence map›Paper›PMID 22596383›Full record

SynthesisBMJ (Clinical research ed.)2012

Effects of interventions in pregnancy on maternal weight and obstetric outcomes: meta-analysis of randomised evidence.

S Thangaratinam, E Rogozinska, K Jolly, S Glinkowski, T Roseboom, J W Tomlinson, R Kunz, B W Mol, A Coomarasamy, K S Khan

6 registry-linked trialsOpen access · hybridAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMJ (Clinical research ed.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 6 registered trials, which are not on this map. Cited by 349 papers, 29 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
349citing papers in PubMed, 29 pooled it
77.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02394158 phase4unknown statusstarted 2015, after this paper: background citation

Preventing Recurrent Gestational Diabetes Mellitus With Early Metformin Intervention

Ran2015Enrolled112Registered outcomes11Posted comparisons0ConditionsGestational Diabetes MellitusArmsMetformin, Placebo
PMID 18463376PMID 20630491PMID 18463375PMID 21530058other papers from this trial
Open the trial in the graph
NCT02095028 nacompletednot on this map

Effects of Dietary and Lifestyle Interventions in Obese Pregnant Women From the First Trimester on Gestational Weight Gain and Pregnancy Outcomes

TypeinterventionalSponsorCapital Medical UniversityRan2011 to 2012Enrolled373ConditionsObesity, Weight Gain, Lifestyle, Pregnancy RelatedArmsDietary and lifestyle intervention
NCT02701426 nacompletednot on this mapstarted 2016, after this paper: background citation

Obesity and Pregnancy : Study of Factors Influencing Participation in a Program Combining Physical Activity and Nutritional Counseling

TypeinterventionalSponsorUniversity Hospital, LilleRan2016 to 2018Enrolled195ConditionsObesity, Overweight, PregnancyArmsphysical activity and nutritional counseling
NCT03146156 nacompletednot on this mapstarted 2017, after this paper: background citation

Lifestyle Intervention in Preparation for Pregnancy (LIPP)

TypeinterventionalSponsorTufts Medical CenterRan2017 to 2025Enrolled99ConditionsObesity, Lifestyle-related Condition, Macrosomia, FetalArmsLifestyle Intervention
NCT03607799 naactive not recruitingnot on this mapstarted 2020, after this paper: background citation

A Culturally-tailored Personalized Nutrition Intervention in South Asian Women at Risk of Gestational Diabetes Mellitus

TypeinterventionalSponsorMcMaster UniversityRan2020 to 2025Enrolled140ConditionsDiabetes, GestationalArmsDietary Intervention, Control
NCT06932250 narecruitingnot on this mapstarted 2025, after this paper: background citation

Vascular and Neural Mechanisms of Chronic Leg Heating in Pregnant Women With Obesity

TypeinterventionalSponsorUniversity of Texas Southwestern Medical CenterRan2025 to 2030Enrolled118ConditionsHigh-risk PregnancyArmsLeg heating
3 · Its place in the literature

Who cites it

349 citing papers in PubMed, 29 syntheses or guidelines pooled it, 789 citations in OpenAlex.

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289 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 3 countries.

S ThangaratinamWomen's Health Research Unit, Centre for Primary Care and Public Health, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, UK. s.thangaratinam@qmul.ac.uk
E Rogozinska
K Jolly
S Glinkowski
T Roseboom
J W Tomlinson
R Kunz
B W Mol
A Coomarasamy
K S Khan
Queen Mary University of London · GBUniversity of Birmingham · GBAcademic Medical Center · NLUniversity of Basel · CH

Funding

Department of Health 09/27/06
6 · The paper itself

Abstract

objectiveTo evaluate the effects of dietary and lifestyle interventions in pregnancy on maternal and fetal weight and to quantify the effects of these interventions on obstetric outcomes.

designSystematic review and meta-analysis. DATA SOURCES: Major databases from inception to January 2012 without language restrictions. STUDY SELECTION: Randomised controlled trials that evaluated any dietary or lifestyle interventions with potential to influence maternal weight during pregnancy and outcomes of pregnancy. DATA SYNTHESIS: Results summarised as relative risks for dichotomous data and mean differences for continuous data.

resultsWe identified 44 relevant randomised controlled trials (7278 women) evaluating three categories of interventions: diet, physical activity, and a mixed approach. Overall, there was 1.42 kg reduction (95% confidence interval 0.95 to 1.89 kg) in gestational weight gain with any intervention compared with control. With all interventions combined, there were no significant differences in birth weight (mean difference -50 g, -100 to 0 g) and the incidence of large for gestational age (relative risk 0.85, 0.66 to 1.09) or small for gestational age (1.00, 0.78 to 1.28) babies between the groups, though by itself physical activity was associated with reduced birth weight (mean difference -60 g, -120 to -10 g). Interventions were associated with a reduced the risk of pre-eclampsia (0.74, 0.60 to 0.92) and shoulder dystocia (0.39, 0.22 to 0.70), with no significant effect on other critically important outcomes. Dietary intervention resulted in the largest reduction in maternal gestational weight gain (3.84 kg, 2.45 to 5.22 kg), with improved pregnancy outcomes compared with other interventions. The overall evidence rating was low to very low for important outcomes such as pre-eclampsia, gestational diabetes, gestational hypertension, and preterm delivery.

conclusionsDietary and lifestyle interventions in pregnancy can reduce maternal gestational weight gain and improve outcomes for both mother and baby. Among the interventions, those based on diet are the most effective and are associated with reductions in maternal gestational weight gain and improved obstetric outcomes.

Indexed as

Diet, ReducingMotor ActivityRisk Reduction BehaviorWeight LossBody Mass IndexBody WeightConfidence IntervalsFemaleHumansInfant, NewbornObesityPregnancyPregnancy ComplicationsPregnancy OutcomePremature BirthRandomized Controlled Trials as Topic

Identifiers

PMID22596383
PMCPMC3355191
OpenAlexW2074585667

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.