Evidence mapPaperPMID 22607889Full record

Trial reportFertility and sterility2012

Body mass index and short-term weight change in relation to treatment outcomes in women undergoing assisted reproduction.

Jorge E Chavarro, Shelley Ehrlich, Daniela S Colaci, Diane L Wright, Thomas L Toth, John C Petrozza, Russ Hauser

Registry-linked trialOpen access · greenAbstract readClinical Trial
In one paragraph

Trial report in Fertility and sterility, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00011713 (Human Exposure to Bisphenol A, Phthalates and Fertility, Pregnancy Outcomes.), which is not on this map. Cited by 57 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 5 pooled it
9.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00011713 completednot on this map

Human Exposure to Bisphenol A, Phthalates and Fertility, Pregnancy Outcomes.

TypeobservationalSponsorNational Institute of Environmental Health Sciences (NIEHS)Ran1999 to 2020Enrolled1,474ConditionsInfertilityArmsCompletion questionnaires/providing biological samples
3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 5 syntheses or guidelines pooled it, 128 citations in OpenAlex.

  1. Pooled it
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  6. Trial
  7. Article
  8. Obesity Affects IVF Outcomes and Mevalonic Acid Rescues the Side Effects of Statins on Follicle Growth.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2025
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  15. Observational
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Jorge E ChavarroDepartment of Nutrition, Harvard School of Public Health, Boston, Massachusetts 02115, USA. jchavarr@hsph.harvard.edu
Shelley Ehrlich
Daniela S Colaci
Diane L Wright
Thomas L Toth
John C Petrozza
Russ Hauser
Massachusetts General Hospital · USHarvard University · US

Funding

TOXICOLOGYP30ES000002 · NIEHS · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · PI Douglas W Dockery · 1985 to 2023
$12.4M
SIGNAL TRANSDUCTION IN HUMAN ABDOMINAL AND GLUTEOFEMORAL ADIPOCYTESP30DK046200 · TUFTS MEDICAL CENTER · 1992 to 2005
$5.3M
PCBs, Phthalates and Male Reproductive HealthR01ES009718 · HARVARD UNIVERSITY (SCH OF PUBLIC HLTH) · 1999 to 2005
$2.9M
NICHD NIH HHS L50 HD056672NIDDK NIH HHS DK46200NIDDK NIH HHS P30 DK046200NIEHS NIH HHS ES000002NIEHS NIH HHS ES009718NIEHS NIH HHS P30 ES000002NIEHS NIH HHS R01 ES009718
6 · The paper itself

Abstract

objectiveTo assess the relation between body mass index (BMI) and short-term weight change with assisted reproductive technology (ART) outcomes.

designProspective cohort study.

settingFertility center. PATIENT(S): A total of 170 women undergoing 233 ART cycles. INTERVENTION(S): Baseline BMI and short-term weight change were related to ART outcomes. Regression models accounting for repeated observations were used to adjust data for potential confounders. MAIN OUTCOME MEASURE(S): Peak E2 levels, oocyte yield, MII yield, fertilization rate, embryo quality, postive [beta]-hCH, clinical pregnancy and live birth rates. RESULT(S): Overweight and obesity were associated with lower live birth rates. The adjusted live birth rate (95% confidence interval) was 42% (28%-58%) among women with a BMI between 20 and 22.4 kg/m(2) and 23% (14%-36%) among overweight or obese women. Short-term weight loss was associated with a higher proportion of metaphase II (MII) oocytes retrieved. The adjusted proportion of MII eggs was 91% (87%-94%) for women who lost 3 kg or more and 86% (81%-89%) for women whose weight remained stable. This association was stronger among women who were overweight or obese at baseline. Short-term weight loss was unrelated to positive β-hCG, clinical pregnancy, or live birth rates. CONCLUSION(S): Overweight and obesity were related to lower live birth rates in women undergoing ART. Short-term weight loss was related to higher MII yield, particularly among overweight and obese women, but unrelated to clinical outcomes.

Indexed as

Body Mass IndexReproductive Techniques, AssistedAdultBody WeightCohort StudiesCombined Modality TherapyFemaleHumansInfertilityMaleObesityOocyte RetrievalOverweightPregnancyPregnancy OutcomeTime Factors

Identifiers

PMID22607889
PMCPMC3389169
OpenAlexW2024892781

What Socratic holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.