Evidence map›Paper›PMID 22608055›Full record

Observational studySurgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery

Effect of bariatric surgery-induced weight loss on renal and systemic inflammation and blood pressure: a 12-month prospective study.

Wiebke K Fenske, Sukhpreet Dubb, Marco Bueter, Florian Seyfried, Karishma Patel, Frederick W K Tam, Andrew H Frankel, Carel W le Roux

2 registry-linked trialsAbstract readComparative StudyObservational Study
PubMed Publisher
In one paragraph

Observational study in Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT01847313. Cited by 70 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 5 pooled it
10.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01847313 phase3completed

Phase 3 Study of the Effect of Glucagon-like-peptide 1 (GLP-1) Receptor Agonism on Renal Outcomes in Humans With Diabetic Kidney Disease

Ran2013Enrolled20Registered outcomes6Posted comparisons0ConditionsDiabetic Kidney DiseaseArmsliraglutide
PMID 20622169PMID 20002084PMID 22691169PMID 21744074PMID 21975753PMID 23173142PMID 22969168PMID 22517736PMID 21537349PMID 21253697PMID 21206136PMID 20856686other papers from this trial
Open the trial in the graph
NCT02150707 completednot on this map

The Differential Effects of Diabetes Therapy on Inflammation

TypeobservationalSponsorUniversity College DublinRan2014 to 2015Enrolled17ConditionsDiabetic Nephropathy, Type 2 DiabetesArmsDipeptidyl-Peptidase IV Inhibitors, Glucagon-Like Peptide 1
3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 5 syntheses or guidelines pooled it, 137 citations in OpenAlex.

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  8. Cardiometabolic Surgery for Treatment of Hypertension.Current hypertension reports · 2026
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10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 3 countries.

Wiebke K FenskeImperial Weight Centre, Department of Investigative Medicine, Imperial College London, London, United Kingdom.
Sukhpreet Dubb
Marco Bueter
Florian Seyfried
Karishma Patel
Frederick W K Tam
Andrew H Frankel
Carel W le Roux
Imperial College London · GBUniversitätsklinikum Würzburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBariatric surgery improves arterial hypertension and renal function; however, the underlying mechanisms and effect of different surgical procedures are unknown. In the present prospective study, we compared the 12-month follow-up results after Roux-en-Y gastric bypass, laparoscopic adjustable gastric banding, and laparoscopic sleeve gastrectomy on weight loss, hypertension, renal function, and inflammatory status.

methodsA total of 34 morbidly obese patients were investigated before, one and 12 months after Roux-en-Y gastric bypass (n = 10), laparoscopic adjustable gastric banding (n = 13), and laparoscopic sleeve gastrectomy (n = 11) for hypertension, kidney function, urinary and serum cytokine levels of macrophage migration inhibitory factor, monocyte chemotactic protein-1, and chemokine ligand-18.

resultsAt 12 months after surgery, the patients in all 3 treatment arms showed a significant decrease in the mean body mass index, mean arterial pressure, and urinary and serum inflammatory markers (all P < .001). The reduction in urinary and serum cytokine levels correlated directly with body weight loss (P < .05). Patients with impaired renal function at baseline (corresponding to serum cystatin C >.8 mg/L) had a marked improvement in renal function 12 months after surgery (P < .05).

conclusionSurgically induced weight loss is associated with a marked decrease in renal and systemic inflammation and arterial hypertension and improvement in renal function in patients with pre-existing renal impairment. These effects appear to be independent of surgical procedure. The improvement in renal inflammation could be 1 of the mechanisms contributing to the beneficial effects of bariatric surgery on arterial blood pressure, proteinuria, and renal function.

Indexed as

AdultBlood PressureBody Mass IndexCreatinineCystatin CCytokinesFemaleGastrectomyGastric BypassGastroplastyHumansHypertensionInflammationLaparoscopyMaleMiddle AgedCreatinineCystatin CCytokinesArterial hypertensionBariatric surgeryObesityProteinuriaRenal and systemic inflammation

Identifiers

PMID22608055
OpenAlexW2157097329

What Socratic holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.