SynthesisThe Cochrane database of systematic reviews2012
Sodium bicarbonate supplements for treating acute kidney injury.
Synthesis in The Cochrane database of systematic reviews, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 36 citations in OpenAlex.
- Sodium bicarbonate supplements for treating acute kidney injury.The Cochrane database of systematic reviews · 2012Pooled it
- Nutrition for Tactical Athletes: Insights, Applications and Research Gaps.Sports medicine (Auckland, N.Z.) · 2026Review
- ACUTE KIDNEY INJURY PRECIPITATED BY HAFF DISEASE IN A 28-YEAR-OLD NIGERIAN MALE "CASE REPORT".Annals of Ibadan postgraduate medicine · 2024Article
- Treatment of Acute Kidney Injury: A Review of Current Approaches and Emerging Innovations.Journal of clinical medicine · 2024Review
- Article
- The Changing Landscape of Acute Kidney Injury in Pregnancy from an Obstetrics Perspective.Journal of clinical medicine · 2019Review
- A Double-Blind, Randomized Control Trial of Rapidly Infused High Strong Ion Difference (SID) Fluid Versus Hartmann's Solution on Acid-Base Status in Sepsis Patients in the Emergency Department.Journal of acute medicine · 2019Article
- Short-term and long-term effects of low serum bicarbonate level at admission in hospitalised patients.Scientific reports · 2019Article
- Metabolic acidosis as a risk factor for the development of acute kidney injury and hospital mortality.Experimental and therapeutic medicine · 2017Article
- Acute kidney injury in the perioperative period and in intensive care units (excluding renal replacement therapies).Annals of intensive care · 2016Review
- Serum bicarbonate may independently predict acute kidney injury in critically ill patients: An observational study.World journal of critical care medicine · 2015Article
- Sodium bicarbonate therapy in patients with metabolic acidosis.TheScientificWorldJournal · 2014Review
- Dose and type of crystalloid fluid therapy in adult hospitalized patients.Perioperative medicine (London, England) · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAcute kidney injury (AKI) is a common, serious, but potentially treatable condition. Because AKI is often associated with acidosis, it has become common practice to recommend administration of sodium bicarbonate to correct acid imbalance.
objectivesTo assess the benefits and harms of the use of sodium bicarbonate for people with AKI. The primary outcome measure was all-cause mortality, and secondary outcome measures were patients' need for renal replacement therapy; return to baseline kidney function; and overall survival. SEARCH
methodsIn November 2011 we searched the Cochrane Renal Group's Specialised Register using keywords relevant to this review. The register is populated using searches of Ovid MEDLINE, the Cochrane Central Register of Controlled Trials, EMBASE and handsearching records from renal-related journals and conference proceedings. SELECTION CRITERIA: All randomised controlled trials (RCTs) that investigated the use of sodium bicarbonate supplements, administered by any route, for the treatment of adults with AKI were to be included. The search strategy did not restrict inclusion based on an upper age limit or publication language. We did not consider inclusion of studies that investigated use of sodium bicarbonate for AKI prevention. DATA COLLECTION AND ANALYSIS: All authors planned to independently assess and extracted information. Information was to be collected on methods, participants, interventions and outcomes. Results were to be expressed as risk ratios (RR) for dichotomous outcomes or as mean differences (MD) for continuous data with 95% confidence intervals (CI). MAIN
resultsAlthough our literature search identified four studies, none of these met our predetermined selection criteria. Hence, no suitable studies were identified for inclusion in this review. AUTHORS'
conclusionsWe found no RCT evidence - supportive or otherwise - for the use of sodium bicarbonate for people with AKI. We concluded that there is an urgent need for well conducted RCTs in this area.
Indexed as
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.