ArticleNitric oxide : biology and chemistry2012
A nanoparticle delivery vehicle for S-nitroso-N-acetyl cysteine: sustained vascular response.
Article in Nitric oxide : biology and chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 33 citations in OpenAlex.
- Recent Advances in Hydrogel-Mediated Nitric Oxide Delivery Systems Targeted for Wound Healing Applications.Pharmaceutics · 2022Review
- The Application of Nitric Oxide for Ocular Hypertension Treatment.Molecules (Basel, Switzerland) · 2021Review
- Control of systemic inflammation through early nitric oxide supplementation with nitric oxide releasing nanoparticles.Free radical biology & medicine · 2020Article
- Harnessing nitric oxide for preventing, limiting and treating the severe pulmonary consequences of COVID-19.Nitric oxide : biology and chemistry · 2020Review
- Photochemistry of nitric oxide and S-nitrosothiols in human skin.Histochemistry and cell biology · 2020Article
- Anti-biofilm activity of garlic extract loaded nanoparticles.Nanomedicine : nanotechnology, biology, and medicine · 2019Article
- HbE/β-Thalassemia and Oxidative Stress: The Key to Pathophysiological Mechanisms and Novel Therapeutics.Antioxidants & redox signaling · 2017Review
- Biodegradable Nanoparticles for Delivery of Therapeutics in CNS Infection.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2017Review
- Recent advances in thromboresistant and antimicrobial polymers for biomedical applications: just say yes to nitric oxide (NO).Biomaterials science · 2016Review
- S-nitrosocaptopril nanoparticles as nitric oxide-liberating and transnitrosylating anti-infective technology.Nanomedicine : nanotechnology, biology, and medicine · 2015Article
- Curcumin-encapsulated nanoparticles as innovative antimicrobial and wound healing agent.Nanomedicine : nanotechnology, biology, and medicine · 2015Article
- Nanocarriers for vascular delivery of anti-inflammatory agents.Annual review of pharmacology and toxicology · 2014Review
- HBOC vasoactivity: interplay between nitric oxide scavenging and capacity to generate bioactive nitric oxide species.Antioxidants & redox signaling · 2013Review
- Article
- Use of nitric oxide nanoparticulate platform for the treatment of skin and soft tissue infections.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnologyReview
- Nanotechnology as a tool to advance research and treatment of non-oncologic urogenital diseases.Therapeutic advances in urologyReview
- Nitric oxide-loaded nano- and microparticle platforms serving as potential new antifungal therapeutics.Fungal biologyArticle
- Nitric oxide generating/releasing materials.Future science OAArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Interest in the development of nitric oxide (NO) based therapeutics has grown exponentially due to its well elucidated and established biological functions. In line with this surge, S-nitroso thiol (RSNO) therapeutics are also receiving more attention in recent years both as potential stable sources of NO as well as for their ability to serve as S-nitrosating agents; S-nitrosation of protein thiols is implicated in many physiological processes. We describe two hydrogel based RSNO containing nanoparticle platforms. In one platform the SNO groups are covalently attached to the particles (SNO-np) and the other contains S-nitroso-N-acetyl cysteine encapsulated within the particles (NAC-SNO-np). Both platforms function as vehicles for sustained activity as trans-S-nitrosating agents. NAC-SNO-np exhibited higher efficiency for generating GSNO from GSH and maintained higher levels of GSNO concentration for longer time (24 h) as compared to SNO-np as well as a previously characterized nitric oxide releasing platform, NO-np (nitric oxide releasing nanoparticles). In vivo, intravenous infusion of the NAC-SNO-np and NO-np resulted in sustained decreases in mean arterial pressure, though NAC-SNO-np induced longer vasodilatory effects as compared to the NO-np. Serum chemistries following infusion demonstrated no toxicity in both treatment groups. Together, these data suggest that the NAC-SNO-np represents a novel means to both study the biologic effects of nitrosothiols and effectively capitalize on its therapeutic potential.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.