ArticleDiabetologia2012
The rise and fall of HbA(1c) as a risk marker for diabetes complications.
Article in Diabetologia, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 50 citations in OpenAlex.
- HbA1c variability as an independent risk factor for diabetic retinopathy: results from a screening program.Acta diabetologica · 2026Article
- HbA1c Variability as an Independent Risk Factor for Microvascular Complications in Type 1 Diabetes.Journal of diabetes science and technology · 2024Article
- Glycemic profile variability as an independent predictor of diabetic retinopathy in patients with type 2 diabetes: a prospective cohort study.Frontiers in endocrinology · 2024Article
- Intensified glycemic control by HbA1c for patients with coronary heart disease and Type 2 diabetes: a review of findings and conclusions.Cardiovascular diabetology · 2023Review
- HbA1c variability as an independent predictor of diabetes retinopathy in patients with type 2 diabetes.Journal of endocrinological investigation · 2021Article
- Comparative predictive ability of visit-to-visit HbA1c variability measures for microvascular disease risk in type 2 diabetes.Cardiovascular diabetology · 2020Article
- Risk factors for development and progression of diabetic retinopathy in Dutch patients with type 1 diabetes mellitus.Acta ophthalmologica · 2018Article
- Article
- Lifestyle and clinical determinants of skin autofluorescence in a population-based cohort study.European journal of clinical investigation · 2016Article
- Metabolic Control and Illness Perceptions in Adolescents with Type 1 Diabetes.Journal of diabetes research · 2016Article
- Risk factors for diabetic retinopathy in northern Chinese patients with type 2 diabetes mellitus.International journal of ophthalmology · 2016Article
- Development and feasibility testing of an intervention to support active lifestyles in youths with type 1 diabetes-the ActivPals programme: a study protocol.Pilot and feasibility studies · 2016Article
- The association between glycemic variability and diabetic cardiovascular autonomic neuropathy in patients with type 2 diabetes.Cardiovascular diabetology · 2015Article
- Diabetes is associated with persistent pain after hip and knee replacement.Acta orthopaedica · 2015Article
- Direct association of visit-to-visit HbA1c variation with annual decline in estimated glomerular filtration rate in patients with type 2 diabetes.Journal of diabetes and metabolic disorders · 2015Article
- Salivary protein glycosylation as a noninvasive biomarker for assessment of glycemia.Journal of diabetes science and technology · 2015Article
- Article
- Observational
- Glycemic variability: both sides of the story.Diabetes care · 2013Article
- Hemoglobin A1c variability as an independent correlate of cardiovascular disease in patients with type 2 diabetes: a cross-sectional analysis of the renal insufficiency and cardiovascular events (RIACE) Italian multicenter study.Cardiovascular diabetology · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is still unclear whether short-term, within-day, variability in glycaemic control is contributory to the development of diabetes micro- or macrovascular complications. However, consistent and compelling data are emerging that longer term fluctuations in glucose, as evidenced by increases in HbA(1c) variability, do indeed add to the mean HbA(1c) value in predicting the risk of microvascular disease. Until now, studies have found this to be the case mainly in type 1 diabetes, but in this issue of Diabetologia (DOI: 10.1007/s00125-012-2572-7 ) an analysis of the Tsukuba Kawai Diabetes Registry in Japan has found that HbA(1c) variability also predicts the risk of nephropathy in type 2 diabetic patients. These observations raise the possibility that reducing rises and falls in HbA(1c) may help avoid hyperglycaemia-related vascular disease without running the same risk of hypoglycaemia that a strategy focusing purely on lower HbA(1c) might incur.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.