ArticleInternational journal of cell biology2012
Oxidative DNA damage in neurons: implication of ku in neuronal homeostasis and survival.
Article in International journal of cell biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Redox modulatory role of DJ-1 in Parkinson's disease.Biogerontology · 2025Review
- Discovery of a Novel Shared Variant AmongInternational journal of genomics · 2024Article
- Striatal oxidative damages and neuroinflammation correlate with progression and survival of Lewy body and Alzheimer diseases.Neural regeneration research · 2022Article
- DNA repair protein DNA-PK protects PC12 cells from oxidative stress-induced apoptosis involving AKT phosphorylation.Molecular biology reports · 2022Article
- Oxidative stress and impaired oligodendrocyte precursor cell differentiation in neurological disorders.Cellular and molecular life sciences : CMLS · 2021Review
- In Barrett's epithelial cells, weakly acidic bile salt solutions cause oxidative DNA damage with response and repair mediated by p38.American journal of physiology. Gastrointestinal and liver physiology · 2020Article
- Amyotrophic lateral sclerosis-associated TDP-43 mutation Q331K prevents nuclear translocation of XRCC4-DNA ligase 4 complex and is linked to genome damage-mediated neuronal apoptosis.Human molecular genetics · 2019Article
- Genetic modification of H2AX renders mesenchymal stromal cell-derived dopamine neurons more resistant to DNA damage and subsequent apoptosis.Cytotherapy · 2016Article
- Induction of DNA double-strand breaks and cellular senescence by human respiratory syncytial virus.Virulence · 2016Article
- Herpes Simplex Virus-Type1 (HSV-1) Impairs DNA Repair in Cortical Neurons.Frontiers in aging neuroscience · 2016Article
- XRCC5 as a risk gene for alcohol dependence: evidence from a genome-wide gene-set-based analysis and follow-up studies in Drosophila and humans.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2015Article
- Calanquinone A induces anti-glioblastoma activity through glutathione-involved DNA damage and AMPK activation.European journal of pharmacology · 2014Article
- New insights into the link between DNA damage and apoptosis.Antioxidants & redox signaling · 2013Review
- DNA damage promotes herpes simplex virus-1 protein expression in a neuroblastoma cell line.Journal of neurovirology · 2013Article
Corrections and comments
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Authors and funding
3 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Oxidative DNA damage is produced by reactive oxygen species (ROS) which are generated by exogenous and endogenous sources and continuously challenge the cell. One of the most severe DNA lesions is the double-strand break (DSB), which is mainly repaired by nonhomologous end joining (NHEJ) pathway in mammals. NHEJ directly joins the broken ends, without using the homologous template. Ku70/86 heterodimer, also known as Ku, is the first component of NHEJ as it directly binds DNA and recruits other NHEJ factors to promote the repair of the broken ends. Neurons are particularly metabolically active, displaying high rates of transcription and translation, which are associated with high metabolic and mitochondrial activity as well as oxygen consumption. In such a way, excessive oxygen radicals can be generated and constantly attack DNA, thereby producing several lesions. This condition, together with defective DNA repair systems, can lead to a high accumulation of DNA damage resulting in neurodegenerative processes and defects in neurodevelopment. In light of recent findings, in this paper, we will discuss the possible implication of Ku in neurodevelopment and in mediating the DNA repair dysfunction observed in certain neurodegenerations.
Identifiers
What Socratic holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the Socratic graph.